Results 81 to 90 of about 84,233 (235)
Classification and characterization of human endogenous retroviruses; mosaic forms are common
Retrovirology, 2016 Human endogenous retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the integrated proviruses to the descendants.
L. Vargiu +7 more
semanticscholar +1 more source
Arthritis &Rheumatology, EarlyView.Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV‐K) element influence its function.
Javier Martínez‐López +156 more
wiley +1 more source
HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
Viruses, 2010 HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits.
Alan D. Frankel, Iván D’Orso
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Dermal Systemic Sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with lncRNA H19 (H19) highlighted as the most upregulated RNA in their cargo compared to healthy control (HC). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz +3 more
wiley +1 more source
Evolution of Foamy Viruses: The Most Ancient of All Retroviruses
Viruses, 2013 Recent evidence indicates that foamy viruses (FVs) are the oldest retroviruses (RVs) that we know and coevolved with their hosts for several hundred million years. This coevolution may have contributed to the non-pathogenicity of FVs, an important factor
Jochen Bodem, Axel Rethwilm
doaj +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Viruses, 2016 Interaction of viral envelope proteins with host cell membranes has been extensively investigated in a number of systems. However, the biological relevance of these interactions in vivo has been hampered by the absence of adequate animal models.
Alix de Brogniez, Jan Mast, Luc Willems
doaj +1 more source
Human endogenous retroviruses and their implication for immunotherapeutics of cancer.
Annals of Oncology, 2018 Human endogenous retroviruses (HERVs) have recently caught increased attention as a potential internal trigger to sensitize tumor cells to immunotherapies. HERVs are remnants of retroviral germline infections that resulted in chromosomal integration into
A. S. Attermann +5 more
semanticscholar +1 more source
Biotechnology Progress, EarlyView.Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal +5 more
wiley +1 more source
Precise Therapy Using the Selective Endogenous Encapsidation for Cellular Delivery Vector System
PharmaceuticsInterindividual variability in drug response is a major problem in the prescription of pharmacological treatments. The therapeutic effect of drugs can be influenced by human genes.
Vacis Tatarūnas +2 more
doaj +1 more source