Results 81 to 90 of about 120,627 (303)

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Anderson, Andrew Wood, Asaoka, Bainbridge, Bartosch, Bartosch, Bartosch, Benjamin L. J. Webb, Berthoux, Besnier, Birke Bartosch, Bock, Greg J. Towers, Hanger, Hatziioannou, Hatziioannou, Hatziioannou, Jonsson, Kaiser, Keckesova, Keckesova, Le Tissier, Lieber, Lin, Martin, Martin, Mortuza, Naviaux, Negre, Neil, Newman, Niebert, Nisole, Oldmixon, Passerini, Patience, Patience, Perez-Caballero, Perron, Rambaut, Sakuma, Schaller, Si, Song, Stoye, Stoye, Stremlau, Stremlau, Stremlau, Takeuchi, Tarlinton, Torsten Schaller, Towers, Towers, Towers, Wilson, Wu, Yap, Yasuhiro Takeuchi, Ylinen, Ylinen, Zufferey   +61 more
core   +2 more sources

Translational control of retroviruses [PDF]

Nature Reviews Microbiology, 2007
All replication-competent retroviruses contain three main reading frames, gag, pol and env, which are used for the synthesis of structural proteins, enzymes and envelope proteins respectively. Complex retroviruses, such as lentiviruses, also code for regulatory and accessory proteins that have essential roles in viral replication.
Laurent Balvay, Bruno Sargueil, Jean-Luc Darlix, Jean-Luc Darlix, Théophile Ohlmann, Théophile Ohlmann, Marcelo Lopez Lastra   +6 more
openaire   +4 more sources

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

How Active Are Porcine Endogenous Retroviruses (PERVs)?

Viruses, 2016
Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation.
Joachim Denner
doaj   +1 more source

Immune Responses to Retroviruses [PDF]

Annual Review of Immunology, 2018
Retroviruses are genome invaders that have shared a long history of coevolution with vertebrates and their immune system. Found endogenously in genomes as traces of past invasions, retroviruses are also considerable threats to human health when they exist as exogenous viruses such as HIV.
Saez-Cirion, Asier, Manel, Nicolas
openaire   +4 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence

mBio, 2019
B cell follicles of the spleen and lymph nodes are immune privileged sites and serve as sanctuaries for infected CD4+ cells in HIV infection. It is assumed that CD8+ T cell responses promote the establishment of the reservoir, as B cell follicles do not ...
Sonja Windmann, Lucas Otto, Camilla Patrizia Hrycak, Anna Malyshkina, Nadine Bongard, Paul David, Matthias Gunzer, Ulf Dittmer, Wibke Bayer   +8 more
doaj   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Anti-viral activity of red microalgal polysaccharides against retroviruses

Cancer Cell International, 2002
Red microalgal polysaccharides significantly inhibited the production of retroviruses (murine leukemia virus- MuLV) and cell transformation by murine sarcoma virus(MuSV-124) in cell culture.
Huleihel Mahmoud M, Souprun Yelena Y, Talyshinsky Marina M   +2 more
doaj   +1 more source

Balance between Retroviral Latency and Transcription: Based on HIV Model

Pathogens, 2020
The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence of the HIV-1 reservoir.
Aneta Pluta, Juan P. Jaworski, César N. Cortés-Rubio   +2 more
doaj   +1 more source