Results 51 to 60 of about 667,568 (265)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Investigating the Effect of Relative Firms Profitability on Stock Return Sensitivity to Industry-Level News [PDF]
مجله دانش حسابداری, 2014 Relative firm profitability within industry as a measure of competitiveness reflects the business strengths and weaknesses of the firm, and affects the reaction of stock returns to industry-level news.
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Stock Return Synchronicity and Analysts’ Forecast Properties
Gadjah Mada International Journal of Business, 2016 Using stock return synchronicity as a measure of a firm’s information environment, our research investigates how the firms’ stock return synchronicity affects analysts’ forecast properties for the accuracy and optimism of the analysts’ annual earnings ...
Joong-Seok Cho +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Atmospheric Science LettersExtreme value theory (EVT) is used as univariate extreme value analysis (EVA) in order to analyze and model the covariates temperature, relative humidity (RH) and the thermal comfort index (humidex) issued from a dataset of 38 years in Tunis.
Semia Cherif
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Journal of Statistical Software, 2012 The R package kerdiest has been designed for computing kernel estimators of the distribution function and other related functions. Because of its usefulness in real applications, the bandwidth parameter selection problem has been considered, and a cross ...
Alejandro Quintela-del-Rio +1 more
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Pain level as a predictor of return to work [PDF]
European Spine Journal, 2003 Dear Editor, In a interesting recent report in your journal [3], Kool et al. attempted to predict return to work in a group of patients with chronic low back pain (LBP) in a prospective study design. They found through regression analysis that behavioral signs (Waddell signs), the Step Test, the pseudo strength test and pain levels of 9 or 10 on a ...
openaire +1 more source