Results 71 to 80 of about 121,135 (301)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Early Administration of Adrenaline for Out‐of‐Hospital Cardiac Arrest: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The use of adrenaline in out‐of‐hospital cardiac arrest (OHCA) patients is still controversial. This study aimed to determine the effects of early pre‐hospital adrenaline administration in OHCA patients.
Liyu Ran, Jinglun Liu, Hideharu Tanaka, Michael W. Hubble, Takyu Hiroshi, Wei Huang   +5 more
doaj   +1 more source

Successful fibrinolytic and therapeutic hypothermic management of cardiac arrest following massive pulmonary embolism [PDF]

Clinical and Experimental Emergency Medicine, 2015
Massive pulmonary embolism (MPE) with hemodynamic instability is a clinical condition with a poor prognosis and high mortality rates. There are no definitive treatment options for cardiac arrest due to MPE. A 52-year-old female presented at our emergency
Eunsil Ko, Jeong Hoon Lee, Minjung Kathy Chae, Tae Rim Lee, Min Seob Sim, Tae Gun Shin, Won Chul Cha, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong   +10 more
doaj   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Factors associated with post-arrest withdrawal of life-sustaining therapy. [PDF]

, 2017
INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis.
Abella, Benjamin S., Gaieski, David F., Grossestreuer, Anne V., Haukoos, Jason S., Ikeda, Daniel J., Moskowitz, Ari, Perman, Sarah M., Wiebe, Douglas J.   +7 more
core   +1 more source

Clinical outcomes of patients with in-hospital witnessed cardiac arrest: effect of co-morbidities

Egyptian Journal of Critical Care Medicine
Introduction Cardiopulmonary resuscitation (CPR) is frequently performed in hospitalized patients after in-hospital cardiac arrest (IHCA), especially in the intensive care unit (ICU) (J Crit Care 24:408-414, 2009).
Yasser Nassar, Sozan Fathy, Sherif Sabri, Ayman Gaber, Sherif Mokhtar   +4 more
doaj   +1 more source

Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest

Scientific Reports, 2023
Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest.
Frederik Nancke Nilsson, Søren Bie-Bogh, Louise Milling, Peter Martin Hansen, Helena Pedersen, Erika F. Christensen, Jens Stubager Knudsen, Helle Collatz Christensen, Fredrik Folke, David Høen-Beck, Ulla Væggemose, Anne Craveiro Brøchner, Søren Mikkelsen   +12 more
doaj   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Outline of the 2005 European Resuscitation Council Guidelines [PDF]

, 2005
Resuscitation guidelines are revised and updated about every 5 years and this happens because resuscitation science continues to advance and clinical guidelines must be updated regularly to reflect these developments and advise healthcare providers ...
Cassar, Mary Rose, Tabone, Diane
core