Serotonin and noradrenaline reuptake inhibitors improve micturition control in mice. [PDF]
Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components.
Marco Redaelli+6 more
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Effect of a Novel Antidepressant and Anticancer Nuc01 on Depression in Cancer Survivors [PDF]
Depression in cancer survivors is commonly treated with serotonin and norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine. These drugs alleviate depressive symptoms by inhibiting the reuptake of serotonin and norepinephrine.
Changchun Yuan+5 more
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Channel Clearance by Perfectly Absorbing Boundaries in Synaptic Molecular Communications
Molecular reuptake is a nature-inspired channel clearance strategy to mitigate intersymbol interference (ISI) in molecular communications. Reuptake is especially important if the communication medium is not cleared of the information-carrying molecules ...
Caglar Koca, Ozgur B. Akan
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Serotonin Reuptake Inhibitor Increases Pseudarthrosis Rates in Anterior Cervical Discectomy and Fusions [PDF]
Study Design Retrospective cohort. Purpose To determine (1) the effects of serotonin reuptake inhibitors in pseudarthrosis rates after anterior cervical decompression and fusion (ACDF) and (2) to identify patient-reported outcome measures in patients ...
Mark James Lambrechts+15 more
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Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. [PDF]
Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies within a single molecule. In clinical settings, combinations of monoamine reuptake inhibitors and
Fei Shen+4 more
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New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations
Serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit the presynaptic neuronal uptake of serotonin and norepinephrine and prolong the effects of the monoamines in the synaptic cleft within the central nervous system, leading to increased ...
David Fanelli, Gregory Weller, Henry Liu
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Selective serotonin reuptake inhibitors and risk for gastrointestinal bleeding [PDF]
The most of the known effects of selective serotonin reuptake inhibitors, beneficial or harmful, are associated with the inhibitory action of the serotonin reuptake transporter.
Batić-Mujanović Olivera+2 more
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Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and ...
Haibo Zhu+9 more
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HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum. [PDF]
HIV-1 and addictive drugs, such as cocaine (COC), may act in combination to produce serious neurological complications. In the present experiments, striatal brain slices from HIV-1 transgenic (Tg) and F344 control female rats were studied.
Mehrak Javadi-Paydar+4 more
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Background: Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder with onset during early childhood. Most studies have reported an elevation in platelet serotonin in persons with autism. The serotonin (5-hydroxytryptamine;
Nagwa A Meguid+2 more
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