Results 61 to 70 of about 1,001,360 (298)

Spatial dynamics of bacterial community in chlorinated drinking water distribution systems supplied with two treatment plants: An integral study of free-living and particle-associated bacteria

Environment International, 2021
With the expansion of cities, the deterioration of drinking water quality undergoing complex and long-distance distribution is gaining increasing attention.
Kaiqin Bian, Chen Wang, Shuyu Jia, Peng Shi, Huaicheng Zhang, Lin Ye, Qing Zhou, Aimin Li   +7 more
doaj   +1 more source

Design reuse research : a computational perspective [PDF]

, 1998
This paper gives an overview of some computer based systems that focus on supporting engineering design reuse. Design reuse is considered here to reflect the utilisation of any knowledge gained from a design activity and not just past designs of ...
Duffy, Alex H.B., Duffy, Sandra M., Smith, Joanne S.   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Characterization and evaluation of Fe2+ and Mn2+ in reservoirs and sediments in the Jianghuai Region

Scientific Reports
A dynamic monitoring study of water quality and sediment was conducted in August 2024 at four drinking water reservoirs in Hefei City (Dafangying, Dongpu, Modun, and Zhongxing Reservoirs).
Kun Wang, Wei Chen, Yuchao Tang, Beiping Zhang, Haixiang Sun, Changnian Wu, Jian Huang, Xianhuai Huang   +7 more
doaj   +1 more source

Facet effect of hematite on the hydrolysis of phthalate esters under ambient humidity conditions

Nature Communications, 2022
With a combined experimental and computational study, Jin et al. demonstrate that hematite nanoparticles can efficiently degrade phthalates under ambient humidity conditions, with a rate strongly dependent on the exposed facet via bidentate coordination ...
Xin Jin, Dingding Wu, Cun Liu, Shuhan Huang, Ziyan Zhou, Hao Wu, Xiru Chen, Meiying Huang, Shaoda Zhou, Cheng Gu   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a resource recycling strategy by optimizing isobutanol production in engineered cyanobacteria using high salinity stress

Biotechnology for Biofuels, 2021
Background Isobutanol is an attractive biofuel with many advantages. Third-generation biorefineries that convert CO2 into bio-based fuels have drawn considerable attention due to their lower feedstock cost and more ecofriendly refining process.
Xiao-Xi Wu, Jian-Wei Li, Su-Fang Xing, Hui-Ting Chen, Chao Song, Shu-Guang Wang, Zhen Yan   +6 more
doaj   +1 more source

The influencing mechanism of manufacturing scene change on process domain knowledge reuse [PDF]

, 2013
It is necessary for a enterprise to reuse outside process domain knowledge to develop intelligent manufacturing technology. The key factors influencing knowledge reuse in digital manufacturing scene are manufacturing activities and PPR (Products ...
Ling, Tiezhang, Liu, Chuang, Wang, Junbiao   +2 more
core