Results 71 to 80 of about 1,001,360 (298)

MCMC-ODPR : primer design optimization using Markov Chain Monte Carlo sampling [PDF]

open access: yes, 2012
Background Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly.
Allaby, Robin G.   +3 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Magnetic microsphere-based portable solid phase extraction device for on-site pre-concentration of organics from large-volume water samples

open access: yesScientific Reports, 2017
In this research a new magnetic material called M88 was fully synthetized and characterized for the extraction of pharmaceutical and personal care products in water samples.
Zhijian Yao   +5 more
doaj   +1 more source

Rotational Heisenberg Inequalities [PDF]

open access: yes, 2015
Since their discovery in 1927, the Heisenberg Inequalities have become an icon of quantum mechanics. Often inappropriately referred to as the Uncertainty Principle, these inequalities relating the standard deviations of the position and momentum ...
Ansermet, Jean-Philippe   +3 more
core   +1 more source

Separating Use and Reuse to Improve Both [PDF]

open access: yes, 2019
Context: Trait composition has inspired new research in the area of code reuse for object oriented (OO) languages. One of the main advantages of this kind of composition is that it makes possible to separate subtyping from subclassing; which is good for ...
Arora, Hrshikesh   +2 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Supporting process reuse in PROMENADE [PDF]

open access: yes, 2002
Process reuse (the ability to construct new processes by assembling already built ones) and process harvesting (the ability to build generic processes that may be further reused, from existing ones) are two crucial issues in process technology.
Franch Gutiérrez, Javier   +1 more
core   +1 more source

Adaptive Pilot Clustering in Heterogeneous Massive MIMO Networks

open access: yes, 2016
We consider the uplink of a cellular massive MIMO network. Acquiring channel state information at the base stations (BSs) requires uplink pilot signaling.
Bengtsson, Mats   +2 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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