Results 91 to 100 of about 614,419 (300)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A spectroscopic study of component C and the extended emission around I Zw 18 [PDF]

, 2001
Long-slit Keck II, 4m Kitt Peak, and 4.5m MMT spectrophotometric data are used to investigate the stellar population and the evolutionary status of I Zw 18C, the faint C component of the nearby blue compact dwarf galaxy I Zw 18. Hydrogen H$\alpha$ and H$\
Cervino M., Craig B. Foltz, Frederic H. Chaffee, Klaus J. Fricke, Legrand F., Legrand F., Legrand F., Lequeux J., Meynet G., Natalia G. Guseva, Pagel B. E. J., Papaderos P., Polychronis Papaderos, Richard F. Green, Tantalo R., Trinh X. Thuan, Vanzi L., Yuri I. Izotov   +17 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Donor–Aniline–Thiophene–Acceptor Emitters: Controlling Charge Transfer and Luminescence Efficiency Through Acceptor Variation

ChemistryEurope
Twelve donor–aniline–thiophene–acceptor chromophores with varying acceptor moieties were synthesized via consecutive lithiation–borylation‐Suzuki‐coupling sequence as potential hybridized localized and charge transfer (HLCT) dyes.
Oliver M. Schützdeller‐Wittek, Thomas J. J. Müller   +1 more
doaj   +1 more source

Photoluminescence modification by high-order photonic band with abnormal dispersion in ZnO inverse opal

, 2008
We measured the angle- and polarization-resolved reflection and photoluminescence spectra of ZnO inverse opals. Significant enhancement of spontaneous emission is observed.
C. López, Heeso Noh, Hui Cao, J. Lim, Mark A. Anderson, Michael Scharrer, Robert P. H. Chang   +6 more
core   +1 more source

Spectral evidence for a powerful compact jet from XTE J1118+480 [PDF]

, 2001
We present observations of the X-ray transient XTE J1118+480 during its Low/Hard X-ray state outburst in 2000, at radio and sub-millimetre wavelengths with the VLA, Ryle Telescope, MERLIN and JCMT.
Deane, J. R., Fender, R. P., Hjellming, R. M., Ogley, R. N., Pooley, G. G., Spencer, R. E., Tilanus, R. P. J.   +6 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Temperature dependent optical properties of single, hierarchically self-assembled GaAs/AlGaAs quantum dots

Nanoscale Research Letters, 2006
We report on the experimental observation of bright photoluminescence emission at room temperature from single unstrained GaAs quantum dots (QDs).
Ulrich SM, Michler P, Benyoucef M, Rastelli A, Schmidt OG   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Time delay neural networks reveal pressure-independent fault rupture processes in laboratory acoustic emission

Communications Earth & Environment
Fault nucleation and growth are central to earthquake hazard. Here we analyse fault development in Alzo granite under triaxial confining pressures of 5–40 MPa using a time-delay neural network applied to multi-parameter acoustic-emission data.
Thomas King, Sergio C. Vinciguerra
doaj   +1 more source