Results 51 to 60 of about 202,266 (264)

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Distant Emission from Mrk 1239: Origin Revealed

, 2022
New X-ray observations of a hybrid Narrow Line Seyfert 1 (NLS1) galaxy Mrk 1239 with joint NuSTAR and XMM-Newton in the 0.3-40.0 keV band are presented. Below 2 keV, direct AGN emission is obscured revealing a complex RGS spectrum rich in emission lines originating from a two-component plasma (collisionally and photoionized) at large distances from the
Buhariwalla, M.Z., Gallo, L.C., Mao, J.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fluorescent emission profiles reveal interspecific differences in three Danube River Basin sturgeon species

Scientific Reports
Biofluorescence is widespread among marine teleosts but has not been reported in sturgeons (Acipenseridae). This exploratory study investigates interspecific differences in fluorescent emission profiles among three Danube River Basin sturgeon species ...
Thomas Juhasz-Dora, Uros Ljubobratovic, Gyula Kovacs, Stein-Kato Lindberg   +3 more
doaj   +1 more source

Warming and redistribution of nitrogen inputs drive an increase in terrestrial nitrous oxide emission factor

Nature Communications, 2022
Soil nitrogen isotopic composition is used to drive the IsoTONE model, which is constrained with measurements of tropospheric nitrous oxide isotopic composition. The model results reveal causes of rising mean global nitrous oxide emission factor.
E. Harris, L. Yu, Y-P. Wang, J. Mohn, S. Henne, E. Bai, M. Barthel, M. Bauters, P. Boeckx, C. Dorich, M. Farrell, P. B. Krummel, Z. M. Loh, M. Reichstein, J. Six, M. Steinbacher, N. S. Wells, M. Bahn, P. Rayner   +18 more
doaj   +1 more source

Reveal the Factors that Influence Carbon Emissions in Indonesia

Jurnal Penelitian Ekonomi dan Bisnis
Tingginya emisi karbon Indonesia merupakan tantangan utama dalam mewujudkan pembangunan berkelanjutan di tengah pertumbuhan ekonomi yang pesat. Penelitian ini mengkaji determinan total emisi karbon di Indonesia, dengan perhatian khusus pada nilai tambah per kapita dari industri manufaktur, kepadatan penduduk, dan Produk Domestik Regional Bruto (PDRB ...
Jevan Aulia Kusuma Dewi, Sukma Ayu Aprilia, Yuliawati Yuliawati   +2 more
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Gallstone Magnesium Distributions from Optical Emission Spectroscopy

Atoms, 2018
This work reports measurements of calcified gallstone elemental compositions using laser-induced optical emission spectroscopy. The experimental results support the importance of the magnesium concentration in gallstone growth.
Ashok K. Pathak, Nilesh K. Rai, Rohit Kumar, Pradeep K. Rai, Awadhesh K. Rai, Christian G. Parigger   +5 more
doaj   +1 more source