Results 61 to 70 of about 201,016 (263)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Donor–Aniline–Thiophene–Acceptor Emitters: Controlling Charge Transfer and Luminescence Efficiency Through Acceptor Variation

ChemistryEurope
Twelve donor–aniline–thiophene–acceptor chromophores with varying acceptor moieties were synthesized via consecutive lithiation–borylation‐Suzuki‐coupling sequence as potential hybridized localized and charge transfer (HLCT) dyes.
Oliver M. Schützdeller‐Wittek, Thomas J. J. Müller   +1 more
doaj   +1 more source

Temperature dependent optical properties of single, hierarchically self-assembled GaAs/AlGaAs quantum dots

Nanoscale Research Letters, 2006
We report on the experimental observation of bright photoluminescence emission at room temperature from single unstrained GaAs quantum dots (QDs).
Ulrich SM, Michler P, Benyoucef M, Rastelli A, Schmidt OG   +4 more
doaj   +1 more source

Reveal the Factors that Influence Carbon Emissions in Indonesia

Jurnal Penelitian Ekonomi dan Bisnis
Tingginya emisi karbon Indonesia merupakan tantangan utama dalam mewujudkan pembangunan berkelanjutan di tengah pertumbuhan ekonomi yang pesat. Penelitian ini mengkaji determinan total emisi karbon di Indonesia, dengan perhatian khusus pada nilai tambah per kapita dari industri manufaktur, kepadatan penduduk, dan Produk Domestik Regional Bruto (PDRB ...
Jevan Aulia Kusuma Dewi, Sukma Ayu Aprilia, Yuliawati Yuliawati   +2 more
openaire   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Time delay neural networks reveal pressure-independent fault rupture processes in laboratory acoustic emission

Communications Earth & Environment
Fault nucleation and growth are central to earthquake hazard. Here we analyse fault development in Alzo granite under triaxial confining pressures of 5–40 MPa using a time-delay neural network applied to multi-parameter acoustic-emission data.
Thomas King, Sergio C. Vinciguerra
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Designing Dual-State and Aggregation-Induced Emissive Luminogens from Lignocellulosic Biosourced Molecules

Molecules
Utilizing lignocellulosic biosourced platforms, we synthesized novel cyanostilbene (CS) derivatives featuring the 3,4-dimethoxyphenyl moiety. These derivatives were investigated for their emission properties in both solution and solid states.
Maelys Bonnot, Nagham Ibrahim, Magali Allain, Pierre Frère   +3 more
doaj   +1 more source