Results 111 to 120 of about 4,447 (297)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Revista Brasileira de Estudos da Presença, 2014 Le présent article propose de reprendre certains aspects théoriques et pratiques de la méthode Feldenkrais, en tant que cette méthode somatique annonce déplacer la perspective d’un travail corporel sur un corps-objet vers celle d’une éducation à certaine
Marie
doaj +2 more sources
, 2008 In a remote Welsh village by the sea, four friends grow up together. Plain but charismatic Del is the ringleader, unstoppable, supremely confident in her ability to get her own way.
Hughes, Tristan
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Mr. et Mme. Prudhomme revenant de la foire aux jambons ...
, 2017 Series: Croquis Parisiens Published in Le Charivari Original text: Mr. et Mme. Prudhomme revenant de la foire aux jambons, - histoire de se décarêmer un brin.https://commons.und.edu/daumier-prints/1337/thumbnail ...
Daumier, Honoré
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
155/56 - EN REVENANT DE l’ASSEMBLÉE
, 2009 « En revenant de l’Assemblée », par Pierre V. Tournier * Assemblée nationale. Mardi 15 septembre 2009. 21h30, mon épouse et moi sommes dans les tribunes du public, invités par un député - c’est la règle -.
Pierre-Victor Tournier
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tuer le père ? Présence et usages de Ronsard dans les œuvres d’Aubigné
VersantsCet article se livre à une analyse systématique des références à Ronsard dans l’œuvre d’Aubigné en croisant localisation spatiale et temporelle, c’est-à-dire en tenant compte de la distribution très large de ces nombreuses références, mais en essayant ...
Julien Goeury
doaj +1 more source