Results 51 to 60 of about 669,579 (283)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Unearthing the Depths of Revenue Precision: A Cutting-Edge Research Agenda for Empowering Agile Finance

open access: yesCroatian Economic Survey
This research explores the dynamic relationship between SIO (Strategic Income Optimization), RPM (Revenue Precision Management), SFM (Strategic Financial Management), IRS (Integrated Revenue Strategy), RDC (Revenue-Driven Culture), and FCC (Financial ...
Enkeleda Lulaj
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Police Killings and Municipal Reliance on Fine-and-Fee Revenue

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2023
High-profile police killings in the United States have drawn attention to how municipalities generate revenue through citations and arrests. This article investigates whether killings by police are more frequent in places that rely on fine-and-fee ...
Brenden Beck
doaj   +1 more source

The Fiscal Regime Comparison of IRAN`s New Petroleum Contract (IPC) with Buy-Back Model: The Case study of Phases 4 & 5 of the South Pars Gas Field [PDF]

open access: yesPizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2018
IRAN`s new petroleum contract is a new generation of service contract which aimed to fix bugs from Buy-Back model. In this model some incentives have inserted to increase contractors' motivations. In this study, we consider fiscal differences and revenue
Hadi Dibavand   +4 more
doaj   +1 more source

Growth and income distributions in four EU economies [PDF]

open access: yes, 2016
Dynamic multi-sectoral and multi-household general equilibrium models are constructed to show how the economies of Germany, France, Spain and the United Kingdom will evolve from 2006 to 2090.
Bhattarai, Keshab
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

open access: yesAging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst   +4 more
wiley   +1 more source

Advertising-based revenue model in digital media market

open access: yesEkonomski Vjesnik, 2020
In the case of advertising-based revenue model, a company creates a digital media product, attracts interaction and engagement of users and then sells access to this audience to advertisers.
Alona Bekh
doaj  

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