Results 211 to 220 of about 5,958,314 (335)

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants. [PDF]

Neuropsychopharmacology, 2023
Jetsonen E, Didio G, Winkel F, Llach Pou M, Boj C, Kuczynski-Noyau L, Võikar V, Guirado R, Taira T, Lauri SE, Castrén E, Umemori J.   +11 more
europepmc   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Relevance of Probabilistic Reversal Learning for Adolescent Drinking Trajectories. [PDF]

Addict Biol
Fröhner JH, Waltmann M, Reiter AMF, Kräplin A, Smolka MN.   +4 more
europepmc   +1 more source

Threat reversal learning and avoidance habits in generalised anxiety disorder. [PDF]

Transl Psychiatry, 2022
Roberts C, Apergis-Schoute AM, Bruhl A, Nowak M, Baldwin DS, Sahakian BJ, Robbins TW.   +6 more
europepmc   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration. [PDF]

Psychedelics (N Y)
Brouns EJ, Ekins TG, Ahmed OJ.
europepmc   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Continuous theta burst stimulation to the medial posterior cerebellum impairs reversal learning in healthy volunteers. [PDF]

Cogn Affect Behav Neurosci
Kruithof ES, Drop EM, Gerits D, Klaus J, Schutter DJLG.   +4 more
europepmc   +1 more source

Impairments in goal-directed action and reversal learning in a proportion of individuals with psychosis. [PDF]

Cogn Affect Behav Neurosci, 2022
Suetani S, Baker A, Garner K, Cosgrove P, Mackay-Sim M, Siskind D, Murray GK, Scott JG, Kesby JP.   +8 more
europepmc   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source