Results 101 to 110 of about 178,854 (310)

EFFICACY OF COMBINED THERAPY IN CHILDREN WITH HIV INFECTION

Педиатрическая фармакология, 2010
To achieve a sustainable virus replication suppression, positive dynamics in clinical and immunologic metrics of children with HIV infection, it is necessary to use the most efficient, safe and convenient patterns of highly active antiretroviral therapy.
E.N. Simovan'yan, V.B. Denisenko
doaj   +2 more sources

Effect of the reverse transcriptase inhibitor efavirenz on 5-azacytidine-induced LINE1 long interspersed repeat expression and genetic instability in acute myeloid leukemia cells

Успехи молекулярной онкологии
Introduction. The use of hypomethylating agents in the treatment of acute myeloid leukemia has increased overall patient survival by 12 %. However, alongside their potent antitumor effect, hypomethylating agents negatively impact genome stability due to ...
Kh. M. Magomedova, I. A. Antonova, M. S. Strelkov, V. A. Nurtdinova, V. T. Cheshchevik, K. I. Kirsanov, G. A. Belitsky, M. G. Yakubovskaya, O. A. Vlasova   +8 more
doaj   +1 more source

Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and Their Interactions with the M184I Mutation on Defining Patterns of Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine [PDF]

, 2013
Hongtao Xu, Susan P. Colby-Germinario, Eugene L. Asahchop, Maureen Oliveira, Matthew McCallum, Susan M. Schader, Ying-Shan Han, Yudong Quan, Stefan G. Sarafianos, Mark A. Wainberg   +9 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Molecular Epidemiological Surveillance of HIV-1 Genotypes and Drug Resistance Profiles in Wuhan, Central China

Viruses
The global distribution of HIV-1 subtypes exhibits significant regional variations, with evolving epidemiological patterns over time. China currently experiences concurrent circulation of multiple HIV-1 subtypes, and the transmission landscape is ...
Qiqi Zhang, Mingzhe Yan, Jingxin Huang, Yujie Liu, Hanji Wang, Sheng Feng, Zheng Dong, Dilihumaer Abulimiti, Youping Wang, Ke Liang, Yong Feng   +10 more
doaj   +1 more source

N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor. [PDF]

J Med Chem, 2023
Lane T, Makarov V, Nelson JAE, Meeker RB, Sanna G, Riabova O, Kazakova E, Monakhova N, Tsedilin A, Urbina F, Jones T, Suchy A, Ekins S.   +12 more
europepmc   +1 more source

Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors [PDF]

, 2017
Rafael Contreras-Galindo, Derek Dube, Koh Fujinaga, Mark H. Kaplan, David M. Markovitz   +4 more
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Impact of preexisting nucleos(t)ide reverse transcriptase inhibitor resistance on the effectiveness of bictegravir/emtricitabine/tenofovir alafenamide in treatment experience patients. [PDF]

AIDS, 2022
Micán R, de Gea Grela A, Cadiñanos J, de Miguel R, Busca C, Bernardino JI, Valencia E, Montes ML, Montejano R, Moreno V, Pérez Valero I, Serrano L, González-García J, Arribas JR, Martín-Carbonero L.   +14 more
europepmc   +1 more source