Results 131 to 140 of about 178,854 (310)

Polymer-prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine.

J Mater Chem B, 2023
Liu C, Hern FY, Shakil A, Temburnikar K, Chambon P, Liptrott N, McDonald TO, Neary M, Flexner C, Owen A, Meyers CF, Rannard SP.   +11 more
europepmc   +1 more source

Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model. [PDF]

Pharmaceutics, 2022
Balogun K, Serghides L.
europepmc   +1 more source

Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice [PDF]

, 2023
Yifan Niu, Yu Liu, Xiang Ma, Lu Liu, Sihong Li, Rui Li, Tao Wang, Houhui Song, Dong Niu   +8 more
openalex   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Adverse perinatal outcomes associated with prenatal exposure to protease-inhibitor-based versus non-nucleoside reverse transcriptase inhibitor-based antiretroviral combinations in pregnant women with HIV infection: a systematic review and meta-analysis. [PDF]

BMC Pregnancy Childbirth, 2023
Saint-Lary L, Benevent J, Damase-Michel C, Vayssière C, Leroy V, Sommet A.   +5 more
europepmc   +1 more source

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

, 2015
Zheng-Yong Wan, Jin Yao, Yuan Tao, Tian-Qi Mao, Xin-Long Wang, Yi-Pei Lu, Haifeng Wang, Hong Yin, Yan Wu, Fen‐Er Chen, Erik De Clercq, Dirk Daelemans, Christophe Pannecouque   +12 more
openalex   +2 more sources

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [PDF]

, 1997
Shoshana Loya, Amira Rudi, Yoel Kashman, Amnon Hizi   +3 more
openalex   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Viral suppression after transition from nonnucleoside reverse transcriptase inhibitor- to dolutegravir-based antiretroviral therapy: A prospective cohort study in Lesotho (DO-REAL study). [PDF]

HIV Med, 2022
Brown JA, Nsakala BL, Mokhele K, Rakuoane I, Muhairwe J, Urda L, Amstutz A, Tschumi N, Klimkait T, Labhardt ND.   +9 more
europepmc   +1 more source

Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors. [PDF]

, 2003
Yann-Érick Claessens, Jean‐Daniel Chiche, Jean-Paul Mira, Alain Cariou   +3 more
openalex   +1 more source