Results 181 to 190 of about 178,854 (310)

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

Low rates of nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor drug resistance in Botswana. [PDF]

AIDS, 2019
Moyo S, Gaseitsiwe S, Zahralban-Steele M, Maruapula D, Nkhisang T, Mokaleng B, Mohammed T, Ditlhako TR, Bareng OT, Mokgethi TP, van Widenfelt E, Pretorius-Holme M, Mine MO, Raizes E, Yankinda EK, Wirth KE, Gaolathe T, Makhema JM, Lockman S, Essex M, Novitsky V.   +20 more
europepmc   +1 more source

Nucleoside Reverse Transcriptase Inhibitor Interaction with Human Equilibrative Nucleoside Transporters 1 and 2. [PDF]

Drug Metab Dispos, 2020
Miller SR, Hau RK, Jilek JL, Morales MN, Wright SH, Cherrington NJ.   +5 more
europepmc   +1 more source

Liver Damage During Treatment with Reverse-Transcriptase Inhibitors in HIV Patients. [PDF]

Giorgiana Nicoleta Lungu, Gheorghe Iulian Diaconescu, Florentina Dumitrescu, Oanca Oana Docea, Radu Mitruţ, Lucian Giubelan, Ovidiu Zlatian, Paul Mitruț   +7 more
openalex   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

, 2016
Shin‐ichi Fukuda, Junichi Fukuhara, Younghee Kim, Benjamin J. Fowler, Tetsuhiro Yasuma, Reo Yasuma, Takako Fukuhara, Nagaraj Kerur, Bradley D. Gelfand, Jayakrishna Ambati   +9 more
openalex   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Xiaomei Chen, Qingqing Hao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen   +5 more
openalex   +1 more source

High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase [PDF]

, 2012
Mark A. Ditzler, Margaret J. Lange, Debojit Bose, Christopher A. Bottoms, Katherine F. Virkler, Andrew W. Sawyer, Angela S. Whatley, William G. Spollen, Scott A. Givan, Donald H. Burke   +9 more
openalex   +1 more source

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice. [PDF]

Open Forum Infect Dis, 2021
Borghetti A, Giacomelli A, Borghi V, Ciccullo A, Dusina A, Fabbiani M, Rusconi S, Zazzi M, Mussini C, Di Giambenedetto S.   +9 more
europepmc   +1 more source