Results 191 to 200 of about 178,854 (310)

Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial DNA and RNA in Human Skeletal Muscle Cells

, 2008
Akihiko Saitoh, Richard Haas, Robert K. Naviaux, Neurita G. Salva, Justine K. Wong, Stephen A. Spector   +5 more
openalex   +1 more source

Once-daily nonnucleoside reverse-transcriptase inhibitor approved [PDF]

, 1998

openalex   +1 more source

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

Prospects of Reverse Transcriptase Inhibitors [PDF]

, 2016
Chang Liu, Xiaohong Kong
openaire   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

, 2014
Anna‐Maria Monforte, Stefania Ferro, Laura De Luca, Giuseppa Lo Surdo, Francesca Morreale, Christophe Pannecouque, Jan Balzarini, Alba Chimirri   +7 more
openalex   +1 more source

In Vivo, Nucleoside Reverse‐Transcriptase Inhibitors Alter Expression of Both Mitochondrial and Lipid Metabolism Genes in the Absence of Depletion of Mitochondrial DNA [PDF]

, 2005
Patrick Mallon, Patrick Unemori, Rebecca Sedwell, Adrienne Morey, Martina Rafferty, Kenneth Williams, Donald J. Chisholm, Katherine Samaras, Sean Emery, Anthony D. Kelleher, David A. Cooper, Andrew Carr, SAMA Investigators   +12 more
openalex   +1 more source

Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

BMEMat, EarlyView.
PlaMnB was formed by cytolysin A‐tumor homing peptides (THP)‐modified bacterial membranes encapsulating the clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) plasmid and manganese dioxide. THP‐containing bacterial membrane enhances PlaMnB vascular permeability and tumor targeting, and after cellular ...
Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang   +9 more
wiley   +1 more source

Nucleos(t)ide reverse transcriptase inhibitor-sparing regimens in the era of standard 3-drug combination therapies for HIV-1 infection. [PDF]

Glob Health Med, 2020
Uchitsubo K, Masuda J, Akazawa T, Inoue R, Tsukada K, Gatanaga H, Terakado H, Oka S.   +7 more
europepmc   +1 more source

Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

, 2012
Santosh N. Mokale, Deepak K. Lokwani, Devanand B. Shinde   +2 more
openalex   +1 more source