Results 111 to 120 of about 2,625,760 (300)

A novel nanoparticle vaccine, based on S1-CTD, elicits robust protective immune responses against porcine deltacoronavirus

Journal of Virology
Porcine deltacoronavirus (PDCoV), an emerging swine pathogen causing severe enteric disease in piglets, poses cross-species transmission risks, including humans.
Qing He, Yawen Zou, Beilei Yu, Qian Yuan, Chenguang Meng, Chenxuan Du, Zhiyong Wang, Jiahao Lian, Shile Luo, Siyu Cao, Wenbing Yang, Dantong Li, Hongyu Lei, Yang Zhan, Wenfeng Zhou, Yi Yang, Naidong Wang   +16 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The (Im)Possibility of Reverse Share Tenancy [PDF]

Under the assumption that the landlord is risk-neutral and the tenant is risk-averse, sharecropping is second-best in that it trades off risk sharing and incentives.
Bellemare, Marc F.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The importance of reverse logistics for retail activity [PDF]

Reverse logistics (RL) refers to a set of programs or competencies aimed at moving products in the reverse direction in the supply chain (i.e., from consumer to producer).
Mihaela Moise
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The utilization of computer planning and 3D-printed guide in the surgical management of a reverse Hill-Sachs lesion

JSES International, 2020
Pierluigi Di Felice Ardente, MD, Fernando Menor Fusaro, MD, Miguel Pérez Abad, MD, Francisco Soldado, MD, PhD, Jordi Querolt Coll, MD   +4 more
doaj   +1 more source

A case of delayed axillary artery aneurysm after reverse shoulder arthroplasty for a shoulder fracture dislocation: a case report

JSES International, 2021
Ko Hirata, MD, Hideyuki Sasanuma, MD, PhD, Takashi Fukushima, MD, PhD, Iijima Y, MD, PhD, Yuichiro Yano, MD, PhD, Sueo Nakama, MD, PhD, Yusuke Takei, MD, Katsushi Takeshita, MD, PhD   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source