Results 181 to 190 of about 124,891 (298)

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Quo Vadis after AEGIS: New Opportunities for Therapies Targeted at Reverse Cholesterol Transport? [PDF]

Curr Atheroscler Rep
Lan NSR, Watts GF.
europepmc   +1 more source

A New Frontier for Reverse Cholesterol Transport [PDF]

, 2017
Kazuhiro Nakaya, Shunichi Takiguchi, Katsunori Ikewaki   +2 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

How Does HDL Participate in Atherogenesis? Antioxidant Activity Versus Role in Reverse Cholesterol Transport. [PDF]

Antioxidants (Basel)
Durrington PN, Bashir B, Soran H.
europepmc   +1 more source

The Liver-Selective Thyromimetic T-0681 Influences Reverse Cholesterol Transport and Atherosclerosis Development in Mice

, 2010
Ivan Tancevski, Egon Demetz, Kathrin Eller, Kristina Duwensee, Julia Hoefer, Christiane Heim, Ursula Stanzl, Andreas Wehinger, Kristina Auer, Regina Karer, Julia Huber, Wilfried Schgoer, Miranda Van Eck, Jonathan Vanhoutte, Catherine Fiévet, Frans Stellaard, Mats Rudling, Josef R. Patsch, Andreas Ritsch   +18 more
openalex   +2 more sources

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Associations of excessive gestational weight gain with changes in components of maternal reverse cholesterol transport and neonatal outcomes. [PDF]

Sci Rep
Derikonjic M, Vekic J, Stefanovic A, Matutinovic MS, Munjas J, Antonic T, Mitrovic M, Ardalic D, Stankovic M, Gojkovic T, Trailovic MM, Ivanisevic J, Stanojevic NB, Jovicic S, Mikovic Z, Zeljkovic A.   +15 more
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice. [PDF]

Front Endocrinol (Lausanne)
Zhao T, Yang W, Pan F, Wang J, Shao W, Chen F, Liu K, Zhao S, Zhao L.   +8 more
europepmc   +1 more source