Results 181 to 190 of about 113,812 (280)

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother.
Fabia de Oliveira Andrade, Vivek Verma, Leena Hilakivi‐Clarke   +2 more
wiley   +1 more source

Elevated HDL Cholesterol is Functionally Ineffective in Cardiac Transplant Recipients: Evidence for Impaired Reverse Cholesterol Transport

, 2006
Dmitri Sviridov, Jaye Chin‐Dusting, Paul Nestel, Bronwyn A. Kingwell, Anh Hoang, Beata Olchawa, Jennifer Starr, Anthony M. Dart   +7 more
openalex   +1 more source

From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport [PDF]

, 2013
Alberto Dávalos, Carlos Fernández‐Hernando   +1 more
openalex   +1 more source

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Self‐Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective

ChemPlusChem, Volume 87, Issue 12, December 2022., 2022
Antimicrobial peptides are an ancient defence against a wide range of microbes. Some can self‐assemble into oligomers and amyloid. Similarities with neurodegenerative diseases support a hypothesis that some diseases are due to aberrant activity of a protective neuropeptide.
Verity Baltutis, Paul D. O'Leary, Lisandra L. Martin   +2 more
wiley   +1 more source

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport [PDF]

, 2015
Laeticia Lichtenstein, Nizar Serhan, Sara Espinosa-Delgado, Aurélie Fabre, Wijtske Annema, Uwe J.F. Tietge, Bernard Robaye, Jean‐Marie Boeynaems, Muriel Laffargue, Bertrand Perret, Laurent O. Martinez   +10 more
openalex   +1 more source

Electrochemical Determination of Gallic Acid in Tea Samples Using Pyramidal Pt Nanoparticles

Advanced Electronic Materials, EarlyView.
A novel electrochemical sensor based on pyramidal Pt nanoparticles for gallic acid detection in black and green tea samples is developed. The sensor is prepared by a simple drop casting of nanoparticles on the electrode surface, without any supporting materials, such as polymer matrices and surfactants.
Tiziano Di Giulio, Maria Antonieta Ramírez‐Morales, Valentina Mastronardi, Giuseppe Mele, Rosaria Brescia, Pier Paolo Pompa, Cosimino Malitesta, Giuseppe Egidio De Benedetto, Mauro Moglianetti, Maria Ada Malvindi, Elisabetta Mazzotta   +10 more
wiley   +1 more source

Genome-Edited Human Pluripotent Stem Cell–Derived Macrophages as a Model of Reverse Cholesterol Transport—Brief Report [PDF]

, 2015
Rajat M. Gupta, Torsten Meißner, Chad A. Cowan, Kiran Musunuru   +3 more
openalex   +1 more source