Results 191 to 200 of about 113,812 (280)

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

Aggregate, EarlyView.
The study reveals that optimizing various parameters of sonodynamic therapy (SDT), including the functional characteristics of sonosensitizers and the optimization of acoustic parameters, can significantly enhance SDT therapeutic efficacy. When combined with chemotherapy, this approach effectively overcomes tumor resistance and induces antitumor immune
Zhuoran Gong, Deshang Hou, Yunxue Xu, Mengxuan Wang, Shiyin Lin, Yingjuan Zheng, Zhifei Dai   +6 more
wiley   +1 more source

Evaluation of ABCA1 gene polymorphism as a prognostic index of fibrosis progression in NAFLD patients

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Dyslipidemias, hepatic steatosis index, and ABCA1 (rs1800977) gene polymorphism CC genotype; were the only independent predictors of advanced fibrosis in NAFLD‐patients. Abstract Introduction It had been evident that non‐alcoholic fatty liver disease (NAFLD) is the new era epidemic.
Samar E. Ghanem, Maha M. Elsabaawy, Mervat M. Abdelkareem, Marwa L. Helal, Warda Othman, Mahitab Elsayed, Dalia M. Elsabaawy, Ashraf El Fert   +7 more
wiley   +1 more source

Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT An illustration of the importance of manual data review for identifying rare intronic variants adjacent to homopolymers is presented here. A 14‐year‐old male with Niemann‐Pick Type C disease confirmed biochemically was only found to have a heterozygous pathogenic variant by molecular analysis. A manual review of the Next Generation Sequencing (
Caroline Gully Brown, Matthew Bower, Matthew Schomaker, Jessica Goldstein, Jeanine Jarnes, Chester B. Whitley, Nishitha R. Pillai   +6 more
wiley   +1 more source

Molecular Stiffening by Macrocycle Clustering

Angewandte Chemie, EarlyView.
Macrocyclic hosts can remotely rigidify part of a molecule, implying that this part need not be included inside a macrocycle to be stiffened. Here, we show that multiple binding by synthetic hosts CB[7] and CB[8] can selectively rigidify fragments of a tetratopic molecule in water causing a gradual stiffening from the periphery to the core.
Hang Yin, Qian Cheng, Roselyne Rosas, Stéphane Viel, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Mehdi Yemloul, Ruibing Wang, Anthony Kermagoret, David Bardelang   +11 more
wiley   +2 more sources

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

195 Stimulation of reverse cholesterol transport potently suppresses HIV-1 replication

, 2009
Michael Bukrinsky
openalex   +1 more source

Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study [PDF]

, 2020
Laura Bordoni, Joanna J. Samulak, Angelika K. Sawicka, Iwona Pelikant‐Małecka, Adrianna Radulska, Łukasz Lewicki, Leszek Kalinowski, Rosita Gabbianelli, Robert A. Olek   +8 more
openalex   +1 more source

Isoselenourea‐Catalyzed Enantioselective Pyrazolo‐Heterocycle Synthesis Enabled by Self‐Correcting Amide and Ester Acylation

Angewandte Chemie, EarlyView.
A highly enantioselective isoselenourea catalyzed route to fused pyrazolo‐pyridone and ‐pyranone heterocycles has been developed. Mechanistic and computational studies highlight the significance of an intermediate amide or ester product derived from 1,2‐addition that can be diverted to the desired pathway through isoselenourea acylation.
Martha I. Prindl, Matthew T. Westwood, Alister S. Goodfellow, Aidan P. McKay, David B. Cordes, Michael Bühl, Andrew D. Smith   +6 more
wiley   +2 more sources

The Liver-Selective Thyromimetic T-0681 Influences Reverse Cholesterol Transport and Atherosclerosis Development in Mice

, 2010
Ivan Tancevski, Egon Demetz, Kathrin Eller, Kristina Duwensee, Julia Hoefer, Christiane Heim, Ursula Stanzl, Andreas Wehinger, Kristina Auer, Regina Karer, Julia Huber, Wilfried Schgoer, Miranda Van Eck, Jonathan Vanhoutte, Catherine Fiévet, Frans Stellaard, Mats Rudling, Josef R. Patsch, Andreas Ritsch   +18 more
openalex   +2 more sources