Results 231 to 240 of about 124,891 (298)
Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome
Cardiovascular Research, 2018 S. D'Amore, J. Härdfeldt, M. Cariello, G. Graziano, M. Copetti, G. di Tullio, M. Piglionica, Natasha Scialpi, C. Sabbà, G. Palasciano, M. Vacca, A. Moschetta +11 moresemanticscholar +1 more sourceObicetrapib alone and in combination with ezetimibe increases reverse cholesterol transport and does not affect VLDL production [PDF]
José A. Inia, Nanda Keijzer, Nicole Worms, Anita van Nieuwkoop, Marc Ditmarsch, J. Wouter Jukema, John J.P. Kastelein, Anita Van Den Hoek, Geurt Stokman, Elsbet Pieterman, P. Hans +10 moreopenalex +1 more sourceResilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes
Advanced Science, EarlyView.Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant +16 morewiley +1 more sourceDisrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response
Advanced Science, EarlyView.Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang +20 morewiley +1 more sourceCRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring
Advanced Science, EarlyView.This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang +10 morewiley +1 more sourceHepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding
Molecular Metabolism, 2017 Lin Zhu, Jeanne Shi, Thao Luu, J. Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, D. Wasserman, M. Linton, J. Stafford +9 moresemanticscholar +1 more sourceExpression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium
, 2009 Keith G. Duncan, Kamran Hosseini, Kent R. Bailey, Hongbo Yang, Rosanna Lowe, Michael T. Matthes, John P. Kane, Matthew M. LaVail, Daniel M. Schwartz, J.L. Duncan +9 moreopenalex +2 more sourcesAnionic Liposomes as Optimal Membrane Fusion Carriers Enabling in Situ Multiplexed Detection of Extracellular Vesicle MicroRNAs
Advanced Science, EarlyView.A novel strategy for in situ multiplexed miRNA analysis of plasma extracellular vesicles (EValarm) has been developed. EValarm enables straightforward detection of different extracellular vesicle miRNAs from plasma samples through systematic screening of liposome surface charges, without requiring complex pretreatment steps, and achieves satisfactory ...Jing‐Yuan Ma, Xiao Wang, Yuhan Cai, Guancheng Wang, Mingze Lu, Kaizheng Feng, Ying Zhao, Xue Wu, Xiaoping Zhang, Haoan Wu, Wei Yu, Ming Ma, Zheng Ge, Yu Zhang +13 morewiley +1 more source
