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Reverse cholesterol transport fluxes
Current Opinion in Lipidology, 2014Reverse cholesterol transport (RCT) is considered a significant component of the atheroprotective effects of HDL. Methods for quantifying flux through the RCT pathway have not been available until recently. There is a need to improve our understanding of HDL function, including the role of RCT in general and individual steps of RCT in particular, on ...
Marc, Hellerstein, Scott, Turner
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1986
Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
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Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
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Acceleration of reverse cholesterol transport
Current Opinion in Cardiology, 2000A low level of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease. Levels of HDL cholesterol and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters.
A, von Eckardstein +2 more
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Reverse cholesterol transport: Physiology and pharmacology
Atherosclerosis, 1991Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of cholesterol from peripheral tissues to the liver and plays a major role in maintaining cholesterol homeostasis in the body. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the ...
G. FRANCESCHINI, P. MADERNA, C. SIRTORI
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Drug control of reverse cholesterol transport
Pharmacology & Therapeutics, 1994Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of excess cholesterol from peripheral tissues to the liver. High-density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis.
G. FRANCESCHINI, J. WERBA, L. CALABRESI
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Cholesterol Efflux and Reverse Cholesterol Transport: Experimental Approaches
Current Medicinal Chemistry, 2016Cholesterol efflux as a key event in reverse cholesterol transport (RCT) is considered now as both diagnostic tool and a promising target for the treatment of atherosclerosis. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Fluorescent tracers and stable isotope-labeled cholesterol
Dmitry Y, Litvinov +3 more
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1994
The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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Reverse cholesterol transport in diabetes mellitus
Diabetes/Metabolism Research and Reviews, 2000There are epidemiological data and experimental animal models relating the development of premature atherosclerosis with defects of the reverse cholesterol transport (RCT) system. In this regard, the plasma concentrations of the high density lipoprotein (HDL) subfractions, of cholesteryl ester transfer protein (CETP), as well as the activity of the ...
E C, Quintão +2 more
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Current Opinion in Lipidology, 1991
New research firmly establishes the reverse cholesterol transport pathway, which carries cholesterol through the high-density lipoprotein, as significant in normal cholesterol homeostasis. Modulation of this pathway by transgenic and pharmacological techniques indicates potential therapeutic functions for increased high-density lipoprotein levels in ...
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New research firmly establishes the reverse cholesterol transport pathway, which carries cholesterol through the high-density lipoprotein, as significant in normal cholesterol homeostasis. Modulation of this pathway by transgenic and pharmacological techniques indicates potential therapeutic functions for increased high-density lipoprotein levels in ...
openaire +1 more source