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Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli +8 more
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Reverse cholesterol transport: Physiology and pharmacology
Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of cholesterol from peripheral tissues to the liver and plays a major role in maintaining cholesterol homeostasis in the body. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the ...
G. FRANCESCHINI, P. MADERNA, C. SIRTORI
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Drug control of reverse cholesterol transport
Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of excess cholesterol from peripheral tissues to the liver. High-density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis.
G. FRANCESCHINI, J. WERBA, L. CALABRESI
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Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis
Lipid disorder and inflammation play critical roles in the development of atherosclerosis. Reverse cholesterol transport is a key event in lipid metabolism. Caveolae and caveolin-1 are in the center stage of cholesterol transportation and inflammation in
Li Qin, Neng Zhu, Ya-Ning Shi
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Acceleration of reverse cholesterol transport
Current Opinion in Cardiology, 2000A low level of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease. Levels of HDL cholesterol and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters.
A, von Eckardstein +2 more
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Reverse cholesterol transport fluxes
Current Opinion in Lipidology, 2014Reverse cholesterol transport (RCT) is considered a significant component of the atheroprotective effects of HDL. Methods for quantifying flux through the RCT pathway have not been available until recently. There is a need to improve our understanding of HDL function, including the role of RCT in general and individual steps of RCT in particular, on ...
Marc, Hellerstein, Scott, Turner
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Measurement of Reverse Cholesterol Transport Pathways in Humans: In Vivo Rates of Free Cholesterol Efflux, Esterification, and Excretion [PDF]
BackgroundReverse cholesterol transport from peripheral tissues is considered the principal atheroprotective mechanism of high-density lipoprotein, but quantifying reverse cholesterol transport in humans in vivo remains a challenge.
Scott Turner, Marc K Hellerstein
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1986
Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
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Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
openaire +2 more sources
An overview of reverse cholesterol transport
Atherosclerosis, 1994Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase.
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