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Drugs Affecting Reverse Cholesterol Transport
1993Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of excess cholesterol from peripheral tissues to the liver. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis.
G. Franceschini +3 more
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Molecular mechanisms of reverse cholesterol transport
Current Opinion in Lipidology, 1996The initial step of reverse cholesterol transport, the efflux of cell cholesterol into the extracellular fluid, has received much attention over the past year. Some studies have provided insights into the mechanism of cholesterol efflux and others have focused on the identity of the extracellular acceptors of cell cholesterol.
P J, Barter, K A, Rye
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Reverse cholesterol transport with acute exercise
Medicine & Science in Sports & Exercise, 1993Physical activity has been shown to be inversely related to coronary heart disease (CHD). The role of high density lipoprotein (HDL) particles in the process of reverse cholesterol transport may be a link between exercise and the prevention of CHD. The aim of the present study was to evaluate the effects of acute exercise on cholesterol efflux (C-EF ...
B N, Campaigne +3 more
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Increased reverse cholesterol transport in athletes
Metabolism, 1993Proposed mechanisms for the cardioprotective benefits of exercise include decreased lipid deposition and increased reverse cholesterol transport (RCT). RCT involves the efflux of tissue free cholesterol into high-density lipoprotein (HDL) particles, esterification by lecithin:cholesterol acyltransferase (LCAT), transfer to other lipoproteins by ...
A K, Gupta +3 more
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1989
Reverse cholesterol transport (RCT) is defined as transport of cholesterol from the periphery (e. g. the arterial wall) to the liver. This pathway is necessary, even in the presence of a strictly regulated cellular cholesterol synthesis and low-density lipoprotein (LDL) receptor-mediated endocytosis, because plasma cholesterol always accumulates in the
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Reverse cholesterol transport (RCT) is defined as transport of cholesterol from the periphery (e. g. the arterial wall) to the liver. This pathway is necessary, even in the presence of a strictly regulated cellular cholesterol synthesis and low-density lipoprotein (LDL) receptor-mediated endocytosis, because plasma cholesterol always accumulates in the
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Reverse cholesterol transport in familial hypercholesterolemia
Current Opinion in Lipidology, 2012Familial hypercholesterolemia is characterized by a major elevation in circulating LDL-cholesterol levels, cholesterol deposition within the arterial wall and an increased risk of premature coronary artery disease. The reverse cholesterol transport (RCT) is now considered as a key process that protects against development of atherosclerosis.
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HDL and arteriosclerosis: beyond reverse cholesterol transport
Atherosclerosis, 2002The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol and the risk of coronary heart disease, the protection of susceptible animals from atherosclerosis by transgenic manipulation of HDL metabolism, and several potentially anti-atherogenic in vitro-properties have made HDL metabolism an interesting target for ...
Jerzy-Roch, Nofer +5 more
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Implications of reverse cholesterol transport: Recent studies
Clinica Chimica Acta, 2015There is a strong epidemiological relationship between high density lipoproteins and atherosclerotic coronary vascular disease (ASCVD). The process of reverse cholesterol transport (RCT) has been hypothesized to help explain this relationship. The corollary that raising HDL should reduce ASCVD is also drawn from this relationship.
Stanley S, Levinson, Stephen G, Wagner
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An overview of reverse cholesterol transport
Atherosclerosis, 1994Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase.
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Molecular regulation of macrophage reverse cholesterol transport
Current Opinion in Cardiology, 2007Macrophage reverse cholesterol transport is one of the key mechanisms mediating the protective effects of high-density lipoproteins on atherosclerosis. This review focuses on the recent developments in our understanding of molecular mechanisms of macrophage reverse transport and regulators that play important roles during this process.Macrophage ...
Xun, Wang, Daniel J, Rader
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