Results 281 to 290 of about 124,891 (298)
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Reverse cholesterol transport in familial hypercholesterolemia
Current Opinion in Lipidology, 2012Familial hypercholesterolemia is characterized by a major elevation in circulating LDL-cholesterol levels, cholesterol deposition within the arterial wall and an increased risk of premature coronary artery disease. The reverse cholesterol transport (RCT) is now considered as a key process that protects against development of atherosclerosis.
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High-density lipoproteins, reverse cholesterol transport and atherogenesis
Nature Reviews Cardiology, 2021H. Pownall +3 more
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HDL and arteriosclerosis: beyond reverse cholesterol transport
Atherosclerosis, 2002The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol and the risk of coronary heart disease, the protection of susceptible animals from atherosclerosis by transgenic manipulation of HDL metabolism, and several potentially anti-atherogenic in vitro-properties have made HDL metabolism an interesting target for ...
Jerzy-Roch, Nofer +5 more
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Implications of reverse cholesterol transport: Recent studies
Clinica Chimica Acta, 2015There is a strong epidemiological relationship between high density lipoproteins and atherosclerotic coronary vascular disease (ASCVD). The process of reverse cholesterol transport (RCT) has been hypothesized to help explain this relationship. The corollary that raising HDL should reduce ASCVD is also drawn from this relationship.
Stanley S, Levinson, Stephen G, Wagner
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An overview of reverse cholesterol transport
Atherosclerosis, 1994Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase.
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Molecular regulation of macrophage reverse cholesterol transport
Current Opinion in Cardiology, 2007Macrophage reverse cholesterol transport is one of the key mechanisms mediating the protective effects of high-density lipoproteins on atherosclerosis. This review focuses on the recent developments in our understanding of molecular mechanisms of macrophage reverse transport and regulators that play important roles during this process.Macrophage ...
Xun, Wang, Daniel J, Rader
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HDL and Reverse Cholesterol Transport.
Circulation research, 2020Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the leading cause of death worldwide. It is well established that cholesterol ester-enriched foam cells are the hallmark of atherosclerotic plaques. Multiple lines of evidence support that enhancing foam cell cholesterol efflux by HDL (high-density lipoprotein ...
Mireille, Ouimet +2 more
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Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020
Gang Wang +9 more
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Gang Wang +9 more
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Rethinking Reverse Cholesterol Transport
Atherosclerosis Supplements, 2018Henry J. Pownall +3 more
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Mechanisms of reversed cholesterol transport.
Agents and actions. Supplements, 1989Reverse cholesterol transport may be defined as the movement of cholesterol from tissues, organs and cells to the liver (hepatocytes). Once cholesterol enters the hepatocyte it may be catabolized to bile acids, excreted into bile as free cholesterol, secreted back into the plasma compartment in lipoproteins or esterified and stored in the liver.
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