Results 51 to 60 of about 230 (201)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Low turnoff loss reverse-conducting IGBT with double n-p-n electron extraction paths

Electronics Letters, 2012
A low turnoff loss snapback-free reverse-conducting insulated-gate bipolar transistor (RC-IGBT) with a novel collector structure is demonstrated. The n-collector is partially enclosed by a floating p-layer (p-float) which acts as a barrier for electrons at low current in the forward conduction state and contributes to the snapback-free forward ...
H. Jiang, B. Zhang, W. Chen, M. Qiao, Z. Li, C. Liu, Z. Rao, B. Dong   +7 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Loss-Driven Design Methodology for MHz-Class GaN QSW Buck Converters with a PCB Air-Core Inductor in SWaP-Constrained Aerospace Applications

Aerospace
Aerospace power systems, including satellites in low earth orbit (LEO) and geostationary earth orbit (GEO), face stringent thermal constraints to minimize size, weight, and power (SWaP).
Jinshu Lin, Hui Li, Shan Yin, Xi Liu, Chen Song, Honglang Zhang, Minghai Dong   +6 more
doaj   +1 more source

Soft Switched Current Fed Dual Active Bridge Isolated Bidirectional Series Resonant DC-DC Converter for Energy Storage Applications

Energies, 2022
This paper proposes a high-frequency isolated current-fed dual active bridge bidirectional DC–DC series resonant converter with an inductive filter for energy storage applications, and a steady-state analysis of the converter is carried out.
Kiran Bathala, Dharavath Kishan, Nagendrappa Harischandrappa   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

In-cell bypass diodes for high-efficiency and shading-tolerant back contact silicon photovoltaic modules

Nature Communications
Partial shading is a common condition in the outdoor deployment of photovoltaic modules, potentially causing significant power loss and severe thermal damage. Limitations of existing solutions in balancing effect and cost necessitate a thorough solution,
Hanbo Tang, Yunpeng Li, Hao Lin, Chaowei Xue, Genshun Wang, Yongyuan Xu, Feng Ye, Liang Fang, Xixiang Xu, Pingqi Gao   +9 more
doaj   +1 more source