Results 101 to 110 of about 2,672,892 (299)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Effect of Current Type and Particle Size on Wear and Corrosion Behaviour of Electroplated Ni-B4C Composite Coatings [PDF]
Iranian Journal of Materials Science and EngineeringNi-B4C nanocomposite coatings were deposited onto a pure Cu substrate using electroplating. Different types of current, including direct current (DC), pulse reverse current (PRC), and unipolar pulse current (PC), were applied using various concentrations
Seyed Ehsan Khadempir +2 more
doaj
III.—On the reversal of the respiratory current in the Decapods [PDF]
Annals and Magazine of Natural History, 1898 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 Influence of pulse and reverse current on the composition, physical-mechanical and functional properties of Ag-W coatings was studed. It's established that adding tungsten oxides to composition of silver coating, depositing with pulse and reverse ...
N. V. Bogush, A. A. Khmyl, L. K. Kushner
doaj
Churn: The High Cost of Principal Turnover [PDF]
, 2014 This new report challenges the myth that developing a strong principal pipeline is where America should be focused. CHURN reveals the multitude of signicant impacts principal turnover has on schools and school systems -- including teachers and students ...
core
Rectification of electronic heat current by a hybrid thermal diode
, 2015 We report the realization of an ultra-efficient low-temperature hybrid heat current rectifier, thermal counterpart of the well-known electric diode.
A Fornieri +32 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source