Results 81 to 90 of about 2,672,892 (299)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of high temperature gallium phosphide rectifiers [PDF]

Large area high performance, GaP rectifiers were fabricated by means of Zn diffusion into vapor phase epitaxial GaP. Devices with an active area of 0.01 sq cm typically exhibit forward voltages of 3 volts for a bias current of 1 ampere and have reverse ...
Craford, M. G., Keune, D. L.
core   +1 more source

Adjustment of the electric current in pulsar magnetospheres and origin of subpulse modulation

, 2012
The subpulse modulation of pulsar radio emission goes to prove that the plasma flow in the open field line tube breaks into isolated narrow streams. I propose a model which attributes formation of streams to the process of the electric current adjustment
A. Levinson, A. Muslimov, A.A. Deshpande, A.G. Muslimov, A.K. Harding, A.K. Harding, A.M. Beloborodov, A.N. Timokhin, A.N. Timokhin, B. Zhang, C.D. Dermer, D. Mitra, F.C. Michel, G.A.E. Wright, G.R. Blumenthal, H.-K. Chang, I. Contopoulos, I.A. Grenier, J. Gil, J. Gil, J.A. Hibschman, J.A. Hibschman, J.K. Daugherty, J.M. Rankin, J.M. Rankin, J.M. Rankin, M.A. Ruderman, N.S. Kardashëv, P. Goldreich, P. Weltevrede, P. Weltevrede, P.N. Arendt Jr., Q. Luo, Q. Luo, R.L. Ingraham, S.J. Sturner, S.J. Sturner, W. Kundt, X.-N. Bai, X.Y. Xia, Y. Lyubarsky, Y.E. Lyubarskij, Yuri Lyubarsky, Z. Medin   +43 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reverse Current in Solar Flares [PDF]

The theory that impulsive X ray bursts are produced by high energy electrons streaming from the corona to the chromosphere is investigated. Currents associated with these streams are so high that either the streams do not exist or their current is ...
Knight, J. W., Sturrock, P. A.
core   +1 more source

Effects of current density on Zn reversibility

Chemical Science
This perspective provides a comprehensive examination of the rate-dependent stability of Zn anodes by comparing and contrasting various nucleation-growth theories and models relevant to current density.
Licheng Miao, Wenqi Jia, Lifang Jiao
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigation of the Relationship between Reverse Current of Crystalline Silicon Solar Cells and Conduction of Bypass Diode

International Journal of Photoenergy, 2012
In the process of crystalline silicon solar cells production, there exist some solar cells whose reverse current is larger than 1.0 A because of silicon materials and process.
Hong Yang, He Wang, Minqiang Wang
doaj   +1 more source

Non-equilibrium spin accumulation in ferromagnetic single-electron transistors

, 1998
We study transport in ferromagnetic single-electron transistors. The non- equilibrium spin accumulation on the island caused by a finite current through the system is described by a generalized theory of the Coulomb blockade.
Bauer, G. E. W., Brataas, Arne, Inoue, J., Nazarov, Yu. V.   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source