Results 111 to 120 of about 4,446,471 (346)

Opportunist to risk manager: reverse engineering the Taylor rule [PDF]

, 2009
Taylor (1993) advocated that the short term policy rate should respond linearly to the inflation rate and to the output gap. The Taylor Rule also seemed to track the federal funds rate over the formative years of the Greenspan regime, then considered to ...
Byrne, Brian
core  

Redesign of Dust Filter Tools in Small and Medium Industries (IKM) by Integrating Reverse Engineering and Root Cause Analysis (RCA)

, 2021
Ika Sasmita Sari, Wiwik Sulistiyowati
openalex   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Reverse Engineering the Yield Curve [PDF]

Prices of riskfree bonds in any arbitrage-free environment are governed by a pricing kernel: given a kernel, we can compute prices of bonds of any maturity we like.
David K. Backus, Stanley E. Zin
core  

Reverse Engineering from Assembler to Formal Specifications via Program Transformations

, 2000
The FermaT transformation system, based on research carried out over the last sixteen years at Durham University, De Montfort University and Software Migrations Ltd., is an industrial-strength formal transformation engine with many applications in ...
Ward, M. P.
core   +1 more source

CAPTIVE: Constrained Adversarial Perturbations to Thwart IC Reverse Engineering [PDF]

, 2021
Amir Hosein Afandizadeh Zargari, Marzieh Ashrafiamiri, Minjun Seo, Sai Manoj Pudukotai Dinakarrao, Mohammed E. Fouda, Fadi Kurdahi   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

FORMATION OF READINESS OF FUTURE TEACHERS OF TECHNICAL DISCIPLINES FOR THE INTRODUCTION OF REVERSE-VARIABLE TECHNOLOGIES OF TEACHING ELECTRICAL ENGINEERING AND ELECTRONICS IN THE SYSTEM OF SECONDARY VOCATIONAL EDUCATION [PDF]

, 2023
A.I. Fialko
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source