Results 121 to 130 of about 330,686 (262)

Reverse engineering of BNIP3 identifies a mitochondrial protective peptide. [PDF]

Nat Commun
Hendgen-Cotta UB, Roth A, Beuck C, Messiha D, Settelmeier S, Shah SB, Korste S, Bravo-Rodriguez K, Blueggel M, Cansiz F, Martins Nascentes Melo L, Roesler J, Meckelmann SW, Schmitz OJ, Kaschani F, Kaiser M, Esfeld S, El Bounkari O, Bernhagen J, Brameyer S, Jung K, Schmitt LI, Leo M, Hagenacker T, Totzeck M, Minor T, Ehrmann M, Tasdogan A, Bayer P, Rassaf T.   +29 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Generating multiple-choice questions using reverse engineering techniques. [PDF]

Med Educ Online
Shin S, Choi J, Hong E, Lee M, Lee M.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Current microfluidic platforms for reverse engineering of cornea. [PDF]

Mater Today Bio, 2023
Li Q, Wong HL, Ip YL, Chu WY, Li MS, Saha C, Shih KC, Chan YK.   +7 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Fork to farm: reverse engineering a food system. [PDF]

Philos Trans R Soc Lond B Biol Sci
Ingram J, Barling D, Bayes N, Cottee J, Dickinson A, Hardman C, Holub E, Jones K, Leadley C, Maguire R, Michaels L, Midgley G, Rajagopalan R, Zhang J, Zurek M.   +14 more
europepmc   +1 more source

Reverse Engineering of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia. [PDF]

J Am Chem Soc, 2023
Ivanov DG, Ivetic N, Du Y, Nguyen SN, Le SH, Favre D, Nazy I, Kaltashov IA.   +7 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Hydraulic geometry hypothesis allows reverse engineering of 3D quasi-equilibrium landscapes from 2D channel networks: Earth, Mars, Titan. [PDF]

Proc Natl Acad Sci U S A
Zhang L, Borse D, Singh A, Pizzuto JE, Fu X, Parker G.   +5 more
europepmc   +1 more source