Results 131 to 140 of about 361,500 (307)
Enriching Reverse Engineering with Feature Analysis
, 2007 System comprehension is a prerequisite for software maintenance and evolution, but it is a time-consuming and costly activity. In an effort to support system comprehension, researchers have devised many different reverse engineering techniques.
Greevy, Orla
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Three Reverse Engineering Patterns
, 1998 Whereas a design pattern describes and discusses a solution to a design problem, a reverse engineering pattern describes how to understand aspects of an object-oriented design and how to identify problems in that design.
Tichelaar, Sander +2 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Lagrangian reverse engineering for regular black holes
Physics Letters BNonlinear extensions of classical Maxwell's electromagnetism are among the prominent candidates for theories admitting regular black hole solutions. A quest for such examples has been fruitful, but mostly unsystematic and littered by the introduction of ...
Ana Bokulić +3 more
doaj +1 more source
Ultrasonic Methods for Reverse Engineering
, 2004 A non-contact reverse engineering technique based on ultrasonic sensors for 3D surface profiling is prresented and applied to proof-of-concept samples.
TETI, ROBERTO
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Reverse-engineering new systems for smooth implementation
, 1999 Reverse-engineering a commercial client-server system from PeopleSoft yielded a valuable resource and proved to be cost-effective. The authors describe the motivations for, approach to, and results of this project, commissioned by the Commonwealth of ...
P Aiken (13637197) +2 more
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