Results 131 to 140 of about 330,686 (262)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Forward and reverse engineering the pain system: from computational neuroscience to neuro-engineering. [PDF]

Pain
Mahajan P, Seymour B.
europepmc   +1 more source

PREE: Heuristic builder for reverse engineering of network protocols in industrial control systems. [PDF]

Forensic Sci Int Digit Investig, 2023
Qasim SA, Jo W, Ahmed I.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Reverse engineering molecules from fingerprints through deterministic enumeration and generative models. [PDF]

J Cheminform
Meyer P, Duigou T, Gricourt G, Faulon JL.   +3 more
europepmc   +1 more source

Reverse Engineering and 3D Printing of Medical Devices for Drug Delivery and Drug-Embedded Anatomic Implants. [PDF]

Polymers (Basel), 2023
Elumalai A, Nayak Y, Ganapathy AK, Chen D, Tappa K, Jammalamadaka U, Bishop G, Ballard DH.   +7 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Evaluation of the Dimensional Accuracy of 3D-Printed Aligners: An In Vitro Study Using Reverse Engineering Analysis. [PDF]

J Funct Biomater
Avolese S, Sanna F, Parrini S, Chiarello G, Lava D, Sedran A, Deregibus A, Scotti N.   +7 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

CDiP technology for reverse engineering of sporadic Alzheimer's disease. [PDF]

J Hum Genet, 2023
Kondo T, Yada Y, Ikeuchi T, Inoue H.
europepmc   +1 more source