Results 141 to 150 of about 361,500 (307)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Advanced Laser Scanning Techniques for Reverse Engineering of Cultural Heritage Artefacts
, 2011 Reverse Engineering (RE) can be defined as the process of duplicating an existing part, subassembly or product, without drawings, documentation or a computer model.
TETI, ROBERTO
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Reverse-engineering graphical innovation: an introduction to graphical regimes
G|A|M|E The Italian Journal of Game Studies, 2013 Technological innovation in the video games industry is a rich area of research that has barely been explored as of yet. Gamers are always clamoring for novelty and a remedy to the oft-decried “sequelitis” that “plagues” the industry, while game ...
Dominic Arsenault, Pierre-Marc Côté
doaj
Software Maintenance and the 3R's - Reverse Engineering, Reengineering and Reuse
, 1994 ion .............................................................................................. 36 4.3.3.2. Slicing ...................................................................................................... 41 4.3.3.3.
Richard G. Prince +4 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Modifiche di Geometrie Acquisite mediante sistemi di Reverse Engineering.
, 2004 I sistemi di scansione e di manipolazione dei dati geometrici hanno avuto, negli ultimi anni, un impressionante sviluppo e notevole diffusione, tuttavia il ciclo completo di Reverse Engineering, ovvero la trasformazione dell'oggetto fisico in un modello ...
G. TANI +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Data re-engineering using formal transformations [PDF]
, 1998 This thesis presents and analyses a solution to the problem of formally re- engineering program data structures, allowing new representations of a program to be developed.
Mortimer, Richard Eric
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source