Results 161 to 170 of about 321,955 (260)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Database reverse engineering based on meta-models

Open Computer Science, 2014
Ristić Sonja, Aleksić Slavica, Čeliković Milan, Dimitrieski Vladimir, Luković Ivan   +4 more
doaj   +1 more source

Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction. [PDF]

Sci Rep
Hanssen KS, Winter-Hjelm N, Niethammer SN, Kobro-Flatmoen A, Witter MP, Sandvig A, Sandvig I.   +6 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Reverse Engineering of Radical Polymerizations by Multi-Objective Optimization. [PDF]

Polymers (Basel)
Fiosina J, Sievers P, Kanagaraj G, Drache M, Beuermann S.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs. [PDF]

Elife
Chardon MK, Wang YC, Garcia M, Besler E, Beauchamp JA, D'Mello M, Powers RK, Heckman CJ.   +7 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Bridging human and machine intelligence: Reverse-engineering radiologist intentions for clinical trust and adoption. [PDF]

Comput Struct Biotechnol J
Awasthi A, Le N, Deng Z, Agrawal R, Wu CC, Van Nguyen H.   +5 more
europepmc   +1 more source