Results 211 to 220 of about 5,819,690 (295)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes. [PDF]

Nat Plants
Zhang S, Liu S, Lai HF, Bender KW, Kim G, Caflisch A, Zipfel C.   +6 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Reverse Engineering of Radical Polymerizations by Multi-Objective Optimization. [PDF]

Polymers (Basel)
Fiosina J, Sievers P, Kanagaraj G, Drache M, Beuermann S.   +4 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity

McCarthy JV, Heroven AC, Ifashe K, Fellermeyer M, Hudson D, Cioaca R, Quastel MN, Yang Y, Cagiada M, Draganov SD, Thorpe CJ, Pinto-Fernández A, Greenshields-Watson A, Gillespie GM, Deane CM, Fernandes RA.   +15 more
europepmc   +1 more source

Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction. [PDF]

Sci Rep
Hanssen KS, Winter-Hjelm N, Niethammer SN, Kobro-Flatmoen A, Witter MP, Sandvig A, Sandvig I.   +6 more
europepmc   +1 more source