Results 191 to 200 of about 361,500 (307)

Reverse engineering of Onivyde® - Irinotecan liposome injection. [PDF]

Int J Pharm
Gan J, Juang V, Wang K, Xia Z, Ackermann R, Yu M, Dorsey KH, Lin W, Wang X, Wang Y, Liang J, Zheng J, Xu X, Park JH, Schwendeman A.   +14 more
europepmc   +1 more source

Correction: Reverse engineering environmental metatranscriptomes clarifies best practices for eukaryotic assembly. [PDF]

BMC Bioinformatics, 2023
Krinos AI, Cohen NR, Follows MJ, Alexander H.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Commercial Hoverboard Reverse Engineering and Repurposing for a Stabilized Platform: A Recyclable Solution for Modular Robotic Bases. [PDF]

Sensors (Basel)
Leblanc A, Tricot L, Briquet D, Aziz Slama M, Delebarre C.   +4 more
europepmc   +1 more source

Identification of Hyperelastic Material Parameters of Elastomers by Reverse Engineering Approach. [PDF]

Materials (Basel), 2022
Yenigun B, Gkouti E, Barbaraci G, Czekanski A.   +3 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Design of orthogonal and portable RNA devices for post-transcriptional regulation by reverse engineering type I toxin-antitoxin systems. [PDF]

Nucleic Acids Res
Yin G, Zhang L, Zhou D, Zhou S, Xu R, Du G, Chen J, Kang Z.   +7 more
europepmc   +1 more source

Reverse Engineering Caged Compounds: Design Principles for their Application in Biology. [PDF]

Angew Chem Int Ed Engl, 2023
Ellis-Davies GCR.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Additive Manufacturing, Thermoplastics, CAD Technology, and Reverse Engineering in Orthopedics and Neurosurgery-Applications to Preventions and Treatment of Infections. [PDF]

Antibiotics (Basel)
Ortis GB, Zapparoli FC, Dantas LR, Suss PH, Soni JF, Mendonça CJA, Loesch GH, Loesch MMON, Tuon FF.   +8 more
europepmc   +1 more source