Results 201 to 210 of about 5,819,690 (295)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Author Correction: Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes. [PDF]

Nat Plants
Zhang S, Liu S, Lai HF, Bender KW, Kim G, Caflisch A, Zipfel C.   +6 more
europepmc   +1 more source

Stimulation-mediated reverse engineering of silent neural networks.

J Neurophysiol, 2023
Ren X, Bok I, Vareberg A, Hai A.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Database reverse engineering based on meta-models

Open Computer Science, 2014
Ristić Sonja, Aleksić Slavica, Čeliković Milan, Dimitrieski Vladimir, Luković Ivan   +4 more
doaj   +1 more source

Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes. [PDF]

Cell Rep
Moakley DF, Campbell M, Anglada-Girotto M, Feng H, Califano A, Au E, Zhang C.   +6 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Adaptive evolution and reverse engineering to explore the low pH tolerance mechanisms of <i>Streptomyces albulus</i>. [PDF]

Appl Environ Microbiol
Liu Y, Liu T, Zhang Y, Wang L, Zhang H, Zhang J, Chen X.   +6 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Designing biological network motif-based controllers by reverse engineering Hill function-type models from linear models. [PDF]

J R Soc Interface
Spurgeon M, Clark T, Spartalis TR, Darlington A, Tang X, Foo M.   +5 more
europepmc   +1 more source