Results 41 to 50 of about 330,686 (262)

Reverse-Engineering the Reader

Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing
Numerous previous studies have sought to determine to what extent language models, pre-trained on natural language text, can serve as useful models of human cognition. In this paper, we are interested in the opposite question: whether we can directly optimize a language model to be a useful cognitive model by aligning it to human psychometric data.
Kiegeland, Samuel, Wilcox, Ethan Gotlieb, Amini, Afra, Reich, David Robert, Cotterell, Ryan   +4 more
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Reverse Engineering Role-Play to Teach Systems Engineering Methods

Education Sciences, 2019
Students engaged in systems engineering education typically lack experience and understanding of the multidisciplinary complexity of systems engineering projects.
Alessandro Bertoni
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A comparison of large language models and model-driven reverse engineering for reverse engineering

Frontiers in Computer Science
Large language models (LLMs) have been extensively researched for programming-related tasks, including program summarisation, over recent years. However, the task of abstracting formal specifications from code using LLMs has been less explored.
Hanan Siala, Kevin Lano
doaj   +1 more source

Methodology for selecting objects for reverse engineering at oil and gas industry enterprises [PDF]

E3S Web of Conferences
The basic methods of reengineering and the possibility of their application at the enterprises of both oil and gas industry and enterprises of defense-industrial complex under the conditions of ensuring technological independence are presented.
Zhukov Aleksandr, Berkutova Tatiana, Zhurenkov Denis, Kolosov Aleksandr, Kheruvimova Svetlana, Kartsan Igor   +5 more
doaj   +1 more source

Reverse engineering web configurators [PDF]

2014 Software Evolution Week - IEEE Conference on Software Maintenance, Reengineering, and Reverse Engineering (CSMR-WCRE), 2014
A Web configurator offers a highly interactive environment to assist users in customising sales products through the selection of configuration options. Our previous empirical study revealed that a significant number of configurators are suboptimal in reliability, efficiency, and maintainability, opening avenues for re-engineering support and ...
Abbasi, Ebrahim Khalil, Acher, Mathieu, Heymans, Patrick, Cleve, Anthony   +3 more
openaire   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source