Results 61 to 70 of about 321,955 (260)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

REVERSE ENGINEERING THE BRAIN [PDF]

International Journal of Machine Consciousness, 2010
Reverse engineering the brain will require a deep understanding of how information is represented and how computation is performed in the brain. What are the functional operations? What are the knowledge data structures? How are messages encoded? How are relationships established and broken? How are images processed?
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Reverse Engineering untuk Analisis Malware Remote Access Trojan

JEPIN (Jurnal Edukasi dan Penelitian Informatika), 2019
Para hacker menggunakan malware Remote Access Trojan untuk merusak sistem kemudian mencuri data para korbannya. Diperlukan analisis mendalam mengenai malware baru-baru ini karena malware dapat berkamuflase seperti sistem tidak dicurigai.
Tesa Pajar Setia, Aldy Putra Aldya, Nur Widiyasono   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A strategy to classify and resolve ambiguities when reverse engineering drawings to CAD models

Cogent Engineering
Oftentimes, designers need to reverse engineer detailed design drawings to create 3D models. These drawings are commonly accepted as complete information sources in design datasets but may contain errors or ambiguities and lead to misinterpretation ...
Pedro Company, Raquel Plumed, Carmen González-Lluch, Manuel Contero, Jorge D. Camba   +4 more
doaj   +1 more source

Reverse Engineering of Intel Microcode Update Structure

IEEE Access, 2020
Microcode update mechanism have been widely used in modern processors. Due to the implementation details are not public, researchers are prevented from gaining any sort of further understanding currently.
Zhiguo Yang, Qingbao Li, Ping Zhang, Zhifeng Chen   +3 more
doaj   +1 more source

Reverse Prompt Engineering

CoRR
We explore a new language model inversion problem under strict black-box, zero-shot, and limited data conditions. We propose a novel training-free framework that reconstructs prompts using only a limited number of text outputs from a language model. Existing methods rely on the availability of a large number of outputs for both training and inference ...
Hanqing Li, Diego Klabjan
openaire   +2 more sources