Results 151 to 160 of about 278,308 (202)

Investigating the reassortment potential and pathogenicity of the S segment in Akabane virus using a reverse genetics system. [PDF]

BMC Vet Res
Na EJ, Jeong CG, Chae SB, Oem JK.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Design and construction of a fast synthetic modified vaccinia virus Ankara reverse genetics system for advancing vaccine development. [PDF]

Front Microbiol
Gao Z, Wang B, Liu T, Zhao Z, Xu J, Zhao X, Zhang Z, Jia Z, Yang Y, Wu S, Chen W, Hou L.   +11 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. [PDF]

PLoS Negl Trop Dis
Mantlo E, Maruyama J, Manning JT, Reyna RA, Huang C, Paessler S.   +5 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

A yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses encoding an eighth subgenomic RNA. [PDF]

J Virol
Duguay BA, Tooley TH, Pringle ES, Rohde JR, McCormick C.   +4 more
europepmc   +1 more source

Establishment of a Reverse Genetics System for Influenza D Virus. [PDF]

J Virol, 2020
Ishida H, Murakami S, Kamiki H, Matsugo H, Takenaka-Uema A, Horimoto T.   +5 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening. [PDF]

Virol Sin
Qin SK, Li KH, Liu BJ, Cao C, Yu DB, Jiang ZG, Wang J, Han YX, Wang F, Qi YL, Sun C, Yu L, Chang JT, Yin X.   +13 more
europepmc   +1 more source