Results 321 to 330 of about 1,758,180 (373)

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, EarlyView.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

Enhancing thermostability of Moloney murine leukemia virus reverse transcriptase through greedy combination of multiple mutant residues. [PDF]

Bioresour Bioprocess
Yang Y, Zhang J, Li Z, Qi H.
europepmc   +1 more source

Clinical progress note: Rubella

Journal of Hospital Medicine, EarlyView.
Abstract Rates of rubella infection and congenital rubella syndrome decreased significantly since the introduction of the rubella vaccine in 1969. Endemic rubella was declared eliminated in the United States in 2004, and since 2012, all rubella cases in the United States have been associated with infections acquired abroad.
Adam E. Gailani, Walter Dehority, Sophie E. Katz   +2 more
wiley   +1 more source

The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMM^Δ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity. [PDF]

Front Aging
Basu K.
europepmc   +1 more source

Identification of a novel small-molecule inhibitor of the HIV-1 reverse transcriptase activity with a non-nucleoside mode of action. [PDF]

Virol J
Yu KL, Shin Y, Kim DE, Kim JA, Kang JE, Singh P, Lee KW, Park CM, Kwon H, Kim S, Bae S, Yoon CH.   +11 more
europepmc   +1 more source

Expression of thermostable MMLV reverse transcriptase in Escherichia coli by directed mutation. [PDF]

AMB Express
Divbandi M, Yamchi A, Nikoo HR, Moradi A, Tabarraei A.   +4 more
europepmc   +1 more source

Correction to "SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression". [PDF]

Mol Oncol
europepmc   +1 more source

Production of Reverse Transcriptase and DNA Polymerase in Bacterial Expression Systems. [PDF]

Bioengineering (Basel)
Hriňová K, Dlapová J, Kubala B, Kormanová Ľ, Levarski Z, Struhárňanská E, Turňa J, Stuchlík S.   +7 more
europepmc   +1 more source

Nucleoside reverse transcriptase inhibitors as a therapeutic opportunity to counteract inflammaging and age-related diseases: New evidence from epidemiological data

Olivieri Fabiola, Giuliani Angelica, Massimiliano Bonafè   +2 more
openalex   +1 more source