Results 91 to 100 of about 1,473,689 (294)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Genes involved in carotene synthesis and mating in Blakeslea trispora [PDF]

, 2008
Mating of Blakeslea trispora and other molds of the order Mucorales requires the interaction of mycelia of opposite sex, (+) and (-), leading to the development of specialized structures and to an enhanced accumulation of beta-carotene.
Berg, J.A., van den, Cerda-Olmedo, E., Kuzina, V., Ooyen, A.J.J., van, Ramirez-Medina, H., Visser, H.   +5 more
core   +2 more sources

DYNAMICS OF TICKS’ INFESTATION WITH BORRELIA GENUS BACTERIA AND TICK-BORNE ENCEPHALITIS VIRUS IN KIROV REGION

Инфекция и иммунитет, 2017
Tick-borne encephalitis and tick-borne borreliosis (or Lyme disease) are one of the most known and the most spread transmissible diseases of human. Nowadays it was proved that these diseases are diagnosed among domestic animals as well. Ixodida ticks are
E. A. Bessolitsyna, S. A. Volkov, F. S. Stolbova   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RnaseIII and T4 Polynucleotide Kinase Sequence Biases and Solutions During RNA-Seq Library Construction [PDF]

, 2013
Background: RNA-seq is a next generation sequencing method with a wide range of applications including single nucleotide polymorphism (SNP) detection, splice junction identification, and gene expression level measurement.
Changhoon Lee, Claus O Wilke, Jason K Wall, Lee, Changhoon, R Adron Harris, R Dayne Mayfield   +5 more
core   +3 more sources

THE ANALYSIS OF IXODES TICKS INFESTATION WITH TBEV IN KIROV REGION

Инфекция и иммунитет, 2014
The objects of this study are Ixodes ticks which were collected in different areas of Kirov province. The aim of the study is to determine the proportion of TBEV infected ticks using the reverse transcription and PCR, dependingon time, place, and methods
E. A. Bessolitsyna, S. A. Volkov, F. S. Stolbova, I. V. Darmov   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs. [PDF]

, 2019
Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation.
Chen, Yifang, Harismendy, Olivier, Jones, Jackson, Li, Jingting, Ling, Ji, Sen, George L, Tiwari, Manisha, Wang, Ying, Xu, Xiaojun   +8 more
core   +1 more source

Gene transcription analysis during interaction between potato and Ralstonia solanacearum [PDF]

, 2010
Bacterial wilt (BW) caused by Ralstonia solanacearum (Rs) is an important quarantine disease that spreads worldwide and infects hundreds of plant species. The BW defense response of potato is a complicated continuous process, which involves transcription
Huang, S.W., Jin, L.P., Li, G.C., Qu, D.Y., Vossen, E.A.G., van der, Wang, X.W., Xie, K.Y., Yang, Y.   +7 more
core   +2 more sources

Reverse transcription of plasma-derived HIV-1 RNA generates multiple artifacts through tRNA(Lys-3)-priming

Microbiology Spectrum
In vitro reverse transcription of full-length HIV-1 RNA extracted from the blood plasma of people living with HIV-1 remains challenging. Here, we describe the initiation of reverse transcription of plasma-derived viral RNA in the absence of an exogenous ...
Jarryt Hardy, Els Demecheleer, Marlies Schauvliege, Delfien Staelens, Virginie Mortier, Chris Verhofstede   +5 more
doaj   +1 more source