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TRANSCRIPTION AND REVERSE TRANSCRIPTION OF RETROTRANSPOSONS
Annual Review of Microbiology, 1989Replication des retrotransposons: article de synthese. Presentation des classes principales de retrotransposons. Transcription.
J D, Boeke, V G, Corces
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Expanding the reverse transcription toolbox
Nature Chemistry, 2020Tailor-made reverse transcriptases are used in molecular biology and synthetic genetics. However, re-engineering these enzymes to work with non-natural nucleic acids is difficult and requires powerful directed evolution strategies. Now, an adaptable selection approach has been demonstrated for the evolution of new reverse transcriptases.
Melanie Henkel, Andreas Marx
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Retroviral Recombination and Reverse Transcription
Science, 1990Recombination occurs at a high rate in retroviral replication, and its observation requires a virion containing two different RNA molecules (heterodimeric particles). Analysis of retroviral recombinants formed after a single round of replication revealed that (i) the nonselected markers changed more frequently than expected from the rate of ...
W S, Hu, H M, Temin
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APOBEC3 proteins and reverse transcription
Virus Research, 2008The ability of members of the APOBEC3 (A3) family of proteins to confer intrinsic immunity to retroviral infection was recognized in several studies. More specifically, A3 proteins are cytidine deaminases (CDAs) that cause hypermutations of nascent retroviral genomes by deamination of cytidine residues. Although A3 proteins can restrict the replication
Renato S, Aguiar, B Matija, Peterlin
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Trends in Biochemical Sciences, 1985
Abstract Cauliflower mosaic virus, although a DNA virus, uses RNA as a replicative intermediate and employs reverse transcriptase for genome replication. Details of this replication mode as currently known and implications for other aspects of the life cycle of this virus are presented here.
T. Hohn, B. Hohn, P. Pfeiffer
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Abstract Cauliflower mosaic virus, although a DNA virus, uses RNA as a replicative intermediate and employs reverse transcriptase for genome replication. Details of this replication mode as currently known and implications for other aspects of the life cycle of this virus are presented here.
T. Hohn, B. Hohn, P. Pfeiffer
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Reverse transcription in genome evolution
Cytogenetic and Genome Research, 2005As reverse transcription is predominantly performed by retrotransposable elements, the process is often entirely associated with the propagation of these elements. However, as a unique tool for transmitting information from the dynamic RNA to the more inert DNA, reverse transcription has been instrumental in shaping extant genomes.
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Reverse transcription of the HIV‐1 pandemic
The FASEB Journal, 2007The HIV/AIDS pandemic has existed for >25 years. Extensive work globally has provided avenues to combat viral infection, but the disease continues to rage on in the human population and infected ~4 million people in 2006 alone. In this review, we provide a brief history of HIV/AIDS, followed by analysis of one therapeutic target
Aravind, Basavapathruni +1 more
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Reversible depression of transcription during hibernation
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 2002Mammalian hibernators downregulate processes of energy production and consumption while maintaining cellular homeostasis. Energetic costs of transcription must be balanced with demands for gene products. Data from nuclear run-on assays indicate transcriptional initiation is reduced two fold in torpid golden-mantled ground squirrels ( Spermophilus ...
F, van Breukelen, S L, Martin
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Reverse-Transcription PCR (RT-PCR)
2013RT-PCR is commonly used to test for genetic diseases and to characterize gene expression in various tissue types, cell types, and over developmental time courses. This serves as a form of expression profiling, but typically as a candidate approach. RT-PCR is also commonly used to clone cDNAs for further use with other molecular biology techniques (e.g.,
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