Results 121 to 130 of about 760,511 (339)

L’Éloge du doute en Restauration des œuvres d’art

open access: yesCeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2015
The doubt is a virtue in preservation-restoration. The author, through examples borrowed from the practice, demonstrates his links with the principle of reversibility, the evolution, the progress and the research.
Ségolène Bergeon Langle
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Hysteresis and irreversibility of global drought patterns in response to CO2 mitigation efforts

open access: yesEnvironmental Research Letters
Drought is expected to intensify with rising CO _2 , but its behavior under CO _2 mitigation, remains uncertain. The response of the climate system to CO _2 variation exhibits hysteresis and irreversibility, highlighting the difficulty of recovery and ...
Sanjit Kumar Mondal   +6 more
doaj   +1 more source

Vers une lubrification sèche pour le patrimoine horloger

open access: yesCeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2014
Compared to a traditional lubrication, a solid lubricant coating brings significant benefits such as stability and surface’s protection, and requires no maintenance.
Emilie Cornet
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

A review on realizing rechargeable batteries based on SOCl2/SO2 electrolyte systems

open access: yesMetalMat
As representative high‐energy density primary batteries, Li‐SOCl2 and Li‐SO2 batteries possess superiorities including high working potential, long temperature range, low self‐discharge rate and high safety compared with other conventional primary ...
Xiangyu Gao   +4 more
doaj   +1 more source

Research-Based Contemporary Intervention in Heritage Architecture: The New Doorway of San Juan del Hospital

open access: yesApplied Sciences
The Church of San Juan del Hospital in Valencia (Spain) is a Gothic church whose main architectural feature—the western façade—remained unresolved, posing structural and compositional challenges. The intervention addressed this issue while preserving the
Luis Cortés-Meseguer   +1 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Need of orthogonal approaches in neurological disease modeling in mouse

open access: yesFrontiers in Molecular Neuroscience
Over the years, advancements in modeling neurological diseases have revealed innovative strategies aimed at gaining deeper insights and developing more effective treatments for these complex conditions.
Linda Bossini   +2 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

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