Results 71 to 80 of about 795,603 (249)

Designing DNA codes from reversible self-dual codes over GF(4)

, 2021
We present an explicit method for designing DNA codes from reversible self-dual codes over the finite field GF(4) of order 4. We use Euclidean reversible self-dual codes (Euclidean RSD codes for short) since they have some advantages in designing DNA ...
이윤진
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Describing quaternary codes using binary codes [PDF]

, 2011
PhDFor a quaternary code C of length n, de ne a pair of binary codes fC1;C2g as: -C1 = C mod 2 -C2 = h(C \ 2Zn 4 ) where h is a bijection from 2Z4 to Z2 mapping 0 to 0 and 2 to 1 and for the extension to a map acting coordinatewise.
Al Kharoosi, Fatma Salim Ali
core   +4 more sources

A Meaningful (n, n)-Threshold Visual Secret Sharing Scheme Based on QR Codes and Information Hiding

Mathematics
Visual secret sharing (VSS) schemes can enhance the security of image transmission over networks. Conventional VSS schemes often generate meaningless shares, which can raise suspicion among potential attackers.
Tao Liu, Yongjie Wang, Xuehu Yan, Yanlin Huo, Canju Lu   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reversible Data Hiding in Absolute Moment Block Truncation Codes via Arithmetical and Logical Differential Coding

Cryptography
To reduce bandwidth usage in communications, absolute moment block truncation coding is employed to compress cover images. Confidential data are embedded into compressed images using reversible data-hiding technology for purposes such as image management,
Ching-Chun Chang, Yijie Lin, Jui-Chuan Liu, Chin-Chen Chang   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Post-abortion ban changes in contraceptive method choices, visit type, and patient zip codes in Indiana's statewide contraceptive access initiative: PATH4YOU

Sexual & Reproductive Healthcare
We evaluated the impact of Indiana's abortion ban on Indiana's statewide contraceptive access initiative (PATH4YOU). We analyzed data from 3,012 participants between September 2021–2025 (1,073 pre-ban; 1,939 post-ban), including visit type, contraception
Molly Ruggles, Tracey A. Wilkinson, Brownsyne Tucker Edmonds, Jeffrey F. Peipert, Rebecca Evans, Maria Fernandez, Faith Coleman, Aaron Brehm, Surya S. Bhamidipalli, Steven A. Brown, Kathleen Wendholt, Caitlin Bernard   +11 more
doaj   +1 more source