Results 81 to 90 of about 81,325 (254)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Method for reversing the laser modulation in a storage ring

Physical Review Accelerators and Beams
The pursuit of coherent radiation generation remains a key direction in the advancement of storage ring light sources. Despite the potential of laser modulation in achieving this goal, it leads to a significant decline in the quality of the electron beam.
Weihang Liu, Yu Zhao, Xiao Li, Sheng Wang, Yi Jiao, Chao Feng   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Reverse Homoderivations on (Semi)-prime Rings

Journal of the Indonesian Mathematical Society
In this paper, we explore and examine a new class of maps known as reverse homoderivations. A reverse homoderivation refers to an additive map g defined on a ring T that satisfies the condition, g(ϑℓ)=g(ℓ)g(ϑ)+g(ℓ)ϑ+ℓg(ϑ), for all ϑ,ℓ∈T. We present various results that enhance our understanding of reverse homoderivations, including their existence in ...
Shakir Ali, Naira Noor Rafiquee, Vaishali Varshney, Outdom Dy   +3 more
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Multicolor Luminescent Supramolecular Bidirectional Shuttles Driven by Light

Advanced Science
Possessing special photophysical behavior, supramolecular space‐confined assembly is widely applied in bioimaging, information anti‐counterfeiting, and luminescent materials.
Rong Zhang, Zhuo Lei, Zhiyi Yu, Yong Chen, Yu Liu   +4 more
doaj   +1 more source

Prevalence and associated factors with contraceptive use 1 year after childbirth: a cross-sectional analysis of the pregnancy risk assessment monitoring system

Gynecology and Obstetrics Clinical Medicine
Background Contraceptive use after childbirth can reduce risk of unplanned pregnancy. This study estimated the prevalence of contraception use in the 1 year after childbirth.
Vanessa Perez Patel, Simone Crespi, Seungyoung Hwang, Ryan Irvine, Andrea N Cimino   +4 more
doaj   +1 more source

Ore extensions of zip and reversible rings

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 2006
Bu makalede zip ve reversible halkaların Ore genişlemeleri çalışılmıştır. R bir halka, $\\alpha$; R nin bir endomorfizması ve $\\delta$ bir $\\alpha$-türev olmak üzere; aşağıdakiler ispatlanmıştır. (1) R nin bir sağ zip halka olması için gerek ve yeter koşul R[x; $\\alpha$, $\\delta$ ] nın bir sağ zip halka olmasıdır.
openaire   +3 more sources