Results 91 to 100 of about 1,006,297 (273)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Method for reversing the laser modulation in a storage ring

Physical Review Accelerators and Beams
The pursuit of coherent radiation generation remains a key direction in the advancement of storage ring light sources. Despite the potential of laser modulation in achieving this goal, it leads to a significant decline in the quality of the electron beam.
Weihang Liu, Yu Zhao, Xiao Li, Sheng Wang, Yi Jiao, Chao Feng   +5 more
doaj   +1 more source

Pseudo-Prolines: Reversible Conformational Trap of Cyclosporin C as Novel Concept for Prodrug Design

CHIMIA, 2004
The selective and reversible insertion of pseudo-proline (? Pro) systems in cyclosporin C (CsC) featuring different C(2) substituents at the oxazolidine ring and its impact on the conformational and biological properties is described.
Olivier Turpin, Manfred Mutter, Luc Patiny   +2 more
doaj   +1 more source

Reverse Homoderivations on (Semi)-prime Rings

Journal of the Indonesian Mathematical Society
In this paper, we explore and examine a new class of maps known as reverse homoderivations. A reverse homoderivation refers to an additive map g defined on a ring T that satisfies the condition, g(ϑℓ)=g(ℓ)g(ϑ)+g(ℓ)ϑ+ℓg(ϑ), for all ϑ,ℓ∈T. We present various results that enhance our understanding of reverse homoderivations, including their existence in ...
Shakir Ali, Naira Noor Rafiquee, Vaishali Varshney, Outdom Dy   +3 more
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Ore extensions of zip and reversible rings

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 2006
Bu makalede zip ve reversible halkaların Ore genişlemeleri çalışılmıştır. R bir halka, $\\alpha$; R nin bir endomorfizması ve $\\delta$ bir $\\alpha$-türev olmak üzere; aşağıdakiler ispatlanmıştır. (1) R nin bir sağ zip halka olması için gerek ve yeter koşul R[x; $\\alpha$, $\\delta$ ] nın bir sağ zip halka olmasıdır.
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Multicolor Luminescent Supramolecular Bidirectional Shuttles Driven by Light

Advanced Science
Possessing special photophysical behavior, supramolecular space‐confined assembly is widely applied in bioimaging, information anti‐counterfeiting, and luminescent materials.
Rong Zhang, Zhuo Lei, Zhiyi Yu, Yong Chen, Yu Liu   +4 more
doaj   +1 more source