Results 91 to 100 of about 26,970,723 (329)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

A Review Reviewed [PDF]

open access: yesNature, 1894
I AM rather astonished at the criticism of my use of the term mineraliser in my book on the “Economic Geology of the United States,” made by a reviewer in a recent number of NATURE. Surely the sanction of the Century, Webster, and Worcester dictionaries, besides several scientific works, should be considered as warranting my use of the term, unless ...
openaire   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Effects of intensive care unit quality assessment on changes in medical staff in medical institutions and in-hospital mortality

open access: yesHuman Resources for Health
Background Quality assessments are being introduced in many countries to improve the quality of care and maintain acceptable quality levels. In South Korea, various quality assessments are being conducted to improve the quality of care, but there is ...
Seungju Kim   +3 more
doaj   +1 more source

Roseburg Area \u27Ideal\u27 for Growth of Wine Industry Article [PDF]

open access: yes, 1969
Bjelland Vineyards and Hillcrest Vineyard are used as examples of the opportunities in the wine industry for farmers in the Roseburg area. The newly established Oregon Wine Growers Association (OWGA) has grown to 30 members with as many as 50 attending ...
The News-Review
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

History of OWGA Is Noted Article [PDF]

open access: yes, 1970
The Oregon Wine Grower\u27s Association (OWGA) was created in January 1969 with Paul Bjelland as President, Richard Sommer as Vice President, Ted Anderson, Jr. as Secretary, and Dr. T. R. Mafit as Treasurer.
The News-Review
core   +1 more source

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