Results 51 to 60 of about 5,538,712 (305)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
The top 50 most cited articles on superior capsular reconstruction: a bibliometric analysis
JSES Reviews, Reports, and TechniquesBackground: Bibliometric analysis has been used to quantify and assess a scientific publication and its impact. The purpose of this study was to identify and review the top 50 most cited articles discussing superior capsular reconstruction (SCR). Methods:
Mallery Zeiman, BS +3 more
doaj +1 more source
J@rgonia, 2022 Sterilisaatio on yksi maailman käytetyimmistä ehkäisymenetelmistä, jonka myös osa vapaaehtoisesti lapsettomista henkilöistä katsoo itselleen parhaaksi ehkäisyvaihtoehdoksi.
Väkeväinen, Nina
doaj
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Lihavuus terveyden, sairauden ja normaaliuden määrittelyn kohteena
J@rgonia, 2018 Lihavuudesta ja lihavasta ruumiista on tullut viimeistään viime vuosikymmenen niin kutsutun lihavuusepidemiadiskurssin myötä keskeinen paitsi lääketieteellisen myös sosiaalisen ja moraalisen arvioinnin, yhteiskunnallisen keskustelun ja toimintaohjelmien ...
Hannele Harjunen
doaj
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source