Results 101 to 110 of about 89,980 (338)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

'Big Tigers, Big Data:' Learning Social Reactions to China’s Anticorruption Campaign through Online Feedback [PDF]

, 2019
This study examines the effect of campaign-style anticorruption on political support using the case of China’s most recent anticorruption drive, which stands out for its harsh crackdown on high-ranking officials, or the “big tigers.” An exploratory text ...
Zhang, D, Zhang, Dong, Zhu, Jiangnan, Huang, H, Huang, Huang, Zhu, J   +5 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comprehensive performance assessment and public services improvement in England? A case study of the benefits administration service in local government

, 2011
The purpose of this paper is to independently evaluate the impact of the Comprehensive Performance Assessment regime on one particular public service, namely the provision of Council Tax and Housing Benefits distributed by local authorities throughout ...
Murphy, P, Jones, M, Peter Murphy, Kirsten Greenhalgh, Martin Jones, Greenhalgh, K   +5 more
core   +1 more source

Legislative Controls for Disciplinary Penalties Imposed on Public Servants: A Comparative Analysis of Jordanian and French Legal Frameworks

Sriwijaya Law Review
This study examines the legislative framework governing disciplinary penalties imposed on public servants under the Jordanian Civil Service Regulation of 2020 and the French General Civil Service Law of 2021.
Tareq Al-Billeh
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Limits to civil service and administrative reform in a fragile and conflict affected situation: a case study of Afghanistan 2002-2012 [PDF]

, 2015
This research examined the challenges, decisions, issues, and dilemmas facing the International Community (IC) in attempting to re-establish and rebuild public administration and other government institutions in a country that continues to suffer from ...
Wilson, G. J.
core  

Legal Consequences of State Administrative Decisions That Violate Good Governance: An Analysis of Islamic Law and Positive Law on the SDGs

Profetika
Objective: This study examines the legal consequences of State Administrative Decisions that violate the General Principles of Good Governance (Asas-Asas Umum Pemerintahan yang Baik/AUPB) as regulated in Law Number 30 of 2014 on State Administration ...
Ahmad Rosidi, Awaludin, I Made Suradana, Obydur Rahman   +3 more
doaj   +1 more source