Results 171 to 180 of about 860,986 (290)

Assessment of healthcare financing by older adults during routine consultations in Cameroon. [PDF]

PLOS Glob Public Health
Essi MJ, Abossolo JA, Aba'a DH, Ndjebet SL, Laborde-Balen G, Taverne B, Ciaffi L.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancing Recommendation Systems through SVD-based collaborative filtering and community detection. [PDF]

PLoS One
Keerthika T, Ignisha RG, Rajamani V, Kumar SS, Selvam K, Aiyyappan MR, Babu LST.   +6 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis. [PDF]

PLoS One
Ma J, Xu R, Liu Y, Shao J, Xu J, Qi Y.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Emergency department attendance by callers to NHS111 who end the call prior to triage: A time-to-event-analysis. [PDF]

PLoS One
Pilbery R, Lewis J, Simpson R.
europepmc   +1 more source

Reviewing the review

Southern African Journal of Infectious Diseases
Mark F. Cotton, Andrew C. Whitelaw, Ute Hallbauer, Colleen Bamford, Wolfgang Preiser, Nishi Prabdial-Sing, Nicola Page   +6 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Machine-learning framework for conditional estimation and scenario-based projection of the heat index for public health interventions. [PDF]

PLoS One
Mollah MAH, Binte Ahmed A, Zijan ZI, Joy AA, Rois R.   +4 more
europepmc   +1 more source