Results 91 to 100 of about 8,814,223 (344)

Pornography use and sexting amongst children and young people: a systematic overview of reviews

open access: yesSystematic Reviews, 2020
Background Young people’s use of pornography and participation in sexting are commonly viewed as harmful behaviours. This paper reports findings from a ‘review of reviews’, which aimed to systematically identify and synthesise the evidence on pornography
Gary Raine   +4 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups

open access: yesHealth Technology Assessment, 2014
Background: There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations.
Jane Burch   +8 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Position: The AI Conference Peer Review Crisis Demands Author Feedback and Reviewer Rewards [PDF]

open access: yesarXiv
The peer review process in major artificial intelligence (AI) conferences faces unprecedented challenges with the surge of paper submissions (exceeding 10,000 submissions per venue), accompanied by growing concerns over review quality and reviewer responsibility. This position paper argues for the need to transform the traditional one-way review system
arxiv  

Does routine surveillance imaging after completing treatment for childhood solid tumours cause more harm than good? A systematic review and meta-analysis protocol

open access: yesSystematic Reviews, 2019
Background This systemic review aims to synthesise the current literature surrounding off-therapy surveillance imaging in children and young people with extra-cranial solid tumours, with a view to establishing if routine imaging studies after treatment ...
Jessica E. Morgan   +2 more
doaj   +1 more source

A Review Reviewed [PDF]

open access: yesNature, 1894
I AM rather astonished at the criticism of my use of the term mineraliser in my book on the “Economic Geology of the United States,” made by a reviewer in a recent number of NATURE. Surely the sanction of the Century, Webster, and Worcester dictionaries, besides several scientific works, should be considered as warranting my use of the term, unless ...
openaire   +1 more source

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